DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and TBC1D21

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006720472.1	Gene:	TBC1D21 / 161514	HGNCID:	28536	Length:	399	Species:	Homo sapiens

Alignment Length:	220	Identity:	40/220 - (18%)
Similarity:	89/220 - (40%)	Gaps:	46/220 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 RAEWKAQEKAFEQLN--LESSKTNLTVAVDIVMRRIQ-----EPVRFVIETPVTIQSASEMRIMD 528
            |..:||..:.:|::.  ||:...|.|...:.:.|.||     :|:..|:   :..:...::.::.
Human    91 RKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVL---IDKKRLEKILLLS 152

  Fly   529 HFMSKR--------PMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGM-NNLS 584
            :..:.:        .|.:.|.|.::...|:.|..      :...::..|   |.::.:|: .||.
Human   153 YVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLF------QFFLQKTEH---SCVINIGVAKNLD 208

  Fly   585 RIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSK------DCSQDTLDEWDPILREWD---SE 640
            .:   |::.:..|...:::...      .|.|.|..      .|.|.....:|.:.|.|:   :.
Human   209 ML---STLITFLDPVFAEHLKG------KGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTG 264

  Fly   641 KRPKNLAPLVRLGVPEALREKIWQK 665
            |..:|...||...:.:.:||::.|:
Human   265 KPCRNFQVLVAYSMLQMVREQVLQE 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	13/58 (22%)
		TBC	650..858	CDD:214540	4/16 (25%)
		Phage_Gp23	<914..991	CDD:287621
TBC1D21	XP_006720472.1	TBC	62..287	CDD:214540	39/216 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900