DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and TBC1D16

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_024306344.1	Gene:	TBC1D16 / 125058	HGNCID:	28356	Length:	824	Species:	Homo sapiens

Alignment Length:	979	Identity:	180/979 - (18%)
Similarity:	306/979 - (31%)	Gaps:	376/979 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 STKSSESSITTSGEYEIVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALSSP------ 64
            |:|:|:....|.|      .|...||.....:::..:.   .|...||..|..|....|
Human    11 SSKASDLLTLTPG------GSGSGSPSVLDGEIIYSKN---NVCVHPPEGLQGLGEHHPGYLCLY 66

  Fly    65 -EAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTGS 128
             |.......||.:|...| |.:|.:..:||:.:..|    :|..:.|.| |..::       |.|
Human    67 MEKDEMLGATLILAWVPN-SRIQRQDEEALRYITPE----SSPVRKAPR-PRGRR-------TRS 118

  Fly   129 GGGSVDP---EMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGD 190
            .|.|..|   |:|   ...|||.|:.|..|.|        ..|.:.||||    .:|..|..:|.
Human   119 SGASHQPSPTELR---PTLTPKDEDILVVAQS--------VPDRMLASPA----PEDEEKLAQGL 168

  Fly   191 TTDEEVSEIDQGCT---IFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCS 252
            ..|.........|:   |.|.|         :|:..||..| .....:|.:...|:::      :
Human   169 GVDGAQPASQPACSPSGILSTV---------SPQDVTEEGR-EPRPEAGEEDGSLELS------A 217

  Fly   253 EGLV--VLHDAESNTIIATY---EISSIILYYRGPVDTVENGCFAFTWLHGDALFQCHVFRCHIP 312
            ||:.  ...|::|:|..:.:   .||:.:...||.|           :|..|
Human   218 EGVSRDSSFDSDSDTFSSPFCLSPISAALAESRGSV-----------FLESD------------- 258

  Fly   313 EAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNS 377
                           :.|||.|                       .||..|..|         |.
Human   259 ---------------SSPPSSS-----------------------DAGLRFPDS---------NG 276

  Fly   378 YAAVPR----DRGCFKLRANTDKEVCITVKQTPSNVLQPLHI----ERCFGVLVAPGKLVVQKDM 434
            ....||    .|.|      ..:::| .|.:.....::.|.:    |.|     ..|:|||....
Human   277 LLQTPRWDEPQRVC------ALEQIC-GVFRVDLGHMRSLRLFFSDEAC-----TSGQLVVASRE 329

  Fly   435 HLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDI 499
               ..:.:.:...||.      |..:.....|.|....:.|.|:.|.::..::
Human   330 ---SQYKVFHFHHGGL------DKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQ------------ 373

  Fly   500 VMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEIT 564
                                          |..:||..                     ||.|.
Human   374 ------------------------------FSIRRPKL---------------------PSSET- 386

  Fly   565 EQPGHQQSSSLLKMG----MNNLSRIVRSSSIASIEDDC---PSDYSSDGDEPLLSGTGEVSKDC 622
                |.:.|...::|    :|:|      :.:..:|::.   .:.:....|   :|..|||
Human   387 ----HPEESMYKRLGVSAWLNHL------NELGQVEEEYKLRKAIFFGGID---VSIRGEV---- 434

  Fly   623 SQDTLDEWDPILR----EWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMND--KYKI 681
                   |..:||    |..||:|             ||||         ::.|.|.::  :.::
Human   435 -------WPFLLRYYSHESTSEER-------------EALR---------LQKRKEYSEIQQKRL 470

  Fly   682 LITKE------TKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSF 740
            .:|.|      ...:..:.:|:.||...::.|:.......:::.::...|||::..|||.||:|.
Human   471 SMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSD 535

  Fly   741 IAASLLLH-MPEEDAFCVLVALMYD------------------------------YGLRDLYKAG 774
            :.|.:|.. :.|.|.|...|.||.:                              .|....:.|.
Human   536 LVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLEEWTWETAPKCALRVGSLPGHGAA 600

  Fly   775 FEVL-------------------------YLRLYQLERLIKDQLPKLHEHFTACGIE--THMYAS 812
            ..||                         :.|...|..|::....:.::|..:.|.:  ..::..
Human   601 ASVLPRPGTTLCLTLDHTTASGTVRSGRNWQRQLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCH 665

  Fly   813 QWFLTLYTARFP---------LCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDL--RQLDFEGI 866
            :|.|..:...||         .|:..:..|.|.|       .:.|.:::|...|:  :||..:.:
Human   666 RWLLLCFKREFPEAEALRIWEACWAHYQTDYFHL-------FICVAIVAIYGDDVIEQQLATDQM 723

  Fly   867 LKYF 870
            |.:|
Human   724 LLHF 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	22/135 (16%)
		DUF3694	429..523	CDD:289256	10/93 (11%)
		TBC	650..858	CDD:214540	48/282 (17%)
		Phage_Gp23	<914..991	CDD:287621
TBC1D16	XP_024306344.1	TBC	424..709	CDD:214540	59/327 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810