DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and TBC1D8

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_005263919.1	Gene:	TBC1D8 / 11138	HGNCID:	17791	Length:	1162	Species:	Homo sapiens

Alignment Length:	953	Identity:	200/953 - (20%)
Similarity:	341/953 - (35%)	Gaps:	286/953 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 TIRAEWKAQEKAFEQ-LNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMS 532
            |||...:.:|:.|.. |||:.....:....|:.:||:.:  ..|.:....:|..|::...|....
Human   241 TIRITTQNKERDFSMFLNLDEVFKVMEQLADVTLRRLLD--NEVFDLDPDLQEPSQITKRDLEAR 303

  Fly   533 KRPMTLRFYLHLKRTEE-------SNW------------------------------------KV 554
            .:....|.:..|.|.|:       |.|                                    :|
Human   304 AQNEFFRAFFRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREV 368

  Fly   555 NSIDPSEEITEQPGH-----------------QQSSSLLKMGMNNLSRIVRSSSI---ASIEDDC 599
            .||:..|:.:..| |                 :...||::..:..|.::..:..:   .|.:||.
Human   369 VSIEKMEDTSLLP-HPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDM 432

  Fly   600 PS------DYSSD---GDEPLLSGTGEVSKDCSQDTLDEWDPIL--------------------- 634
            .|      ...||   ||..::|...      |:::..|..|::
Human   433 ASLVFHSTSMCSDHRFGDLEMMSSQN------SEESEKEKSPLMHPDALVTAFQQSGSQSPDSRM 491

  Fly   635 -RE------WDSE----------KRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKIL 682
             ||      |:..          .|.:.:..||.:|:||:||.::|...::....:..:..|...
Human   492 SREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGN 556

  Fly   683 ITKET--KCETV---IQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIA 742
            :.:|:  ||..|   |:||:||:.|.|..|:  ..:|..||.:|..|||..:.::||||.::.:.
Human   557 LVEESLGKCCLVTEEIERDLHRSLPEHPAFQ--NETGIAALRRVLTAYAHRNPKIGYCQSMNILT 619

  Fly   743 ASLLLHMPEEDAFCVLVA----LMYDYGLRDLYKAGFEVLYLRLYQ--LERLIKDQLPKLHEHFT 801
            :.|||:..||:||.:|||    ::.||       ....|:..::.|  .|.|||..||:|.||..
Human   620 SVLLLYTKEEEAFWLLVAVCERMLPDY-------FNHRVIGAQVDQSVFEELIKGHLPELAEHMN 677

  Fly   802 ACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDL-------- 858
            .......:..| |||||:.:..||....:|:|.|..||:..:||:.:.:|.....||
Human   678 DLSALASVSLS-WFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQ 741

  Fly   859 ------RQLD------------------FEGILKYFRVT-LPKKCRSSSQARKVMKQACER---- 894
                  |.||                  |....:.:.|| :....|.|.:  |...|:.|:
Human   742 ALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYE--KFGDQSVEQIEHL 804

  Fly   895 ----KIKKLKQYEEEFLLKKQH------------KERLEKEAQIYENR-----FGEERRKMQAEI 938
                :|:.|:.:|:   ..||:            .|.||:...:::..     :.|:.|.|.:..
Human   805 RYKHRIRVLQGHED---TTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPMASRH 866

  Fly   939 DALNKQLTSAKERAVEKEK--------------KHTGIIQEYKQIIQRQEQDMNTLSETLGKVMH 989
            |.....   |::..::..:              .||.|:.|  :..:..:.:|:.|.|....|
Human   867 DPSRPY---AEQYRIDARQFAHLFQLVSPWTCGAHTEILAE--RTFRLLDDNMDQLIEFKAFV-- 924

  Fly   990 MVSNCQDCQQQIDAGNDNAK-----------SDDGKNRGQTDAMRN---ANEHPL-------GPL 1033
               :|.|....   |..|.|           :....:|.....:||   :...||       ..:
Human   925 ---SCLDIMYN---GEMNEKIKLLYRLHIPPALTENDRDSQSPLRNPLLSTSRPLVFGKPNGDAV 983

  Fly  1034 DPLNAASQRIREL-------ELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSK 1091
            |......|.|::|       |.||.:....:....||.      |.:...|.....:.:|...:.
Human   984 DYQKQLKQMIKDLAKEKDKTEKELPKMSQREFIQFCKT------LYSMFHEDPEENDLYQAIATV 1042

  Fly  1092 TFNSLQEKVTTRGGHRDNGSGGPMPSFQSYMGQAPTTLSEASSPSGNQEYKTFAFASVGGSPKLP 1156
            |...||   ....|.|.:.||    |.....|:.    ..||:||....    .||..|.:|:..
Human  1043 TTLLLQ---IGEVGQRGSSSG----SCSQECGEE----LRASAPSPEDS----VFADTGKTPQDS 1092

  Fly  1157 SKFQATKLRNSIDSLRNIVVPLDTGKTLAE------NLKQQLQ 1193
            ..|.....|:...||.:|:..|.|.::|..      ::|.:|:
Human  1093 QAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLE 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	13/54 (24%)
		TBC	650..858	CDD:214540	70/218 (32%)
		Phage_Gp23	<914..991	CDD:287621	16/95 (17%)
TBC1D8	XP_005263919.1	PH-GRAM1_TBC1D8	178..276	CDD:270156	9/34 (26%)
		PH-GRAM2_TBC1D8	318..413	CDD:270160	11/95 (12%)
		TBC	527..733	CDD:214540	69/215 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810