Protein Alignment GAPcenA and Tbc1d10c

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_848765.2
• Gene: Tbc1d10c / 108995
• MGIID: 1922072
• Length: 444
• Species: Mus musculus
• Alignment Length: 449
• Identity: 112/449 - (24%)
• Similarity: 183/449 - (40%)
• Gaps: 94/449 - (20%)

  Fly   592 IASIEDDCPSDYSSDGDEPLLSG----------------TGEV-----SKDCSQDTLDEWDPILR 635
            ::.::||.    ||.|.:..|||                :||:     |.|..:....:|..:..
Mouse    10 LSELQDDS----SSLGSDSELSGPSPYRQADRYGFIGGNSGELRLCQPSADLIRQREMKWVEMTL 70

  Fly   636 EWDS--EKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKILITK--ETKCETVIQR 695
            .|:.  .:|.|.:....|.|:|.|||.:.|..|.......:.| ..|:.|...  :.:....|.|
Mouse    71 HWEKTMSRRYKKVKIQCRKGIPSALRARCWPLLCGARMCQKNNPGTYQELAAAPGDPQWMETIGR 135

  Fly   696 DIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVA 760
            |:||.||.|:.|....|.||..|.:|.|||.::..|.||||....:||.||:|:|.|:||..||.
Mouse   136 DLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQ 200

  Fly   761 LMYDYGLRDLYKAGFEVLYLRLYQLE-----RLIKDQLPKLHEHFTACGIETHMYASQWFLTLYT 820
            :.      ::|..|:...::...||:     .|::.|||::::|....|:...:|..:|||.|:|
Mouse   201 IC------EVYLPGYYGPHMEAVQLDAEVFMALLRRQLPRVYKHLQQVGVGPLLYLPEWFLCLFT 259

  Fly   821 ARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQAR 885
            ...|...|..:.|.||.:|..|||:|.:||:.:....:.|          |...|....:....|
Mouse   260 RSLPFPTVLRIWDAFLSEGAKVLFRVGLTLMRLALGTVEQ----------RTACPGLLETLGALR 314

  Fly   886 KVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSA-- 948
            .:..          .|.:||..:.:.|...|.:             |.:|.||.....||:.:
Mouse   315 AIPP----------TQLQEEVFMSQVHSVTLSE-------------RVLQQEIRIQLAQLSKSLP 356

  Fly   949 -----------KERAVEKEKKHTGIIQEYKQIIQR-------QEQDMNTLSETLGKVMH 989
                       ..:|:.:.::..|:.:..|..|.|       :.:......:|.||..|
Mouse   357 GPAPLPQARLPGAQAIFESQQLAGVRESTKPEIPRIVVQPPEEPKPPRRKPQTRGKTFH 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	377..523	CDD:463599
		TBC	650..858	CDD:214540	72/215 (33%)
		SMC_prok_B	<876..>1087	CDD:274008	21/134 (16%)
		TPH	<883..>977	CDD:464007	17/113 (15%)
Tbc1d10c	NP_848765.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		8/25 (32%)
		TBC	87..292	CDD:214540	72/210 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..444		7/33 (21%)
		Interaction with calcineurin. /evidence=ECO:0000250	404..444		4/12 (33%)