DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Tbc1d14

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001106833.1	Gene:	Tbc1d14 / 100855	MGIID:	1098708	Length:	714	Species:	Mus musculus

Alignment Length:	681	Identity:	150/681 - (22%)
Similarity:	241/681 - (35%)	Gaps:	170/681 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 CHIPEAVNQVSACFQ-----KAFQTYPPS--MSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVS 366
            |.:|........|.:     :...|:|.:  .|..|.|....|.|.:.:||...:::.|.|...:
Mouse   126 CPLPSCTPSAPTCSEREQVVRKSSTFPRTGYDSVKLYSPTSKALSRSDNVSVCSVSSLGTELSTT 190

  Fly   367 LEIRER------VAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERC------- 418
            |.:...      |..||.|.|..:        |.|......|..:..|....||.:.|
Mouse   191 LSVSNEDILDLMVTSNSSAIVTLE--------NDDDPQFTDVTLSSINETSDLHQQDCVAETEEG 247

  Fly   419 --------FGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWK 475
                    |........|..:::..|.....:|:...|...:.    ..||:.|.     :.:.:
Mouse   248 RKLKLLHPFSHFFTRNLLARKQNARLDRQRDLGWKLFGKVPLR----ETAQKDSK-----KTQKE 303

  Fly   476 AQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRF 540
            .::||.......|.|.|:...:|.      ||    :.|...|            :..||..|
Mouse   304 YEDKAGRPSRPPSPKQNVRKNLDF------EP----LSTTALI------------LEDRPANL-- 344

  Fly   541 YLHLKRTEESNWKVNSIDPSEEITEQPGHQQ--SSSLLKMGMNNLSRIVRSSSIASIEDDCPSDY 603
                              |::...|...|:|  ...:|:.....|....|...  .:|:.|..:.
Mouse   345 ------------------PAKPAEEAQKHRQQYEEMVLQAKKRELKEAQRRRK--QLEERCKVEE 389

  Fly   604 SSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQ-KLA 667
            |          .|......:.:.|..|:.:   |.|:|    :..|...|:|.::|.|:|. .:.
Mouse   390 S----------IGNAVLTWNNEILPNWETM---WCSKK----VRDLWWQGIPPSVRGKVWSLAIG 437

  Fly   668 NVEGRMEMN--------------DKYKILITKETKCET---------------VIQRDIHRTFPA 703
            |     |:|              ::::.|.|..::.|.               :|:.||.||||
Mouse   438 N-----ELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFP- 496

  Fly   704 HKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAF----------CVL 758
            :.|..:.||...|.|..:..||..:..:|||.||:|||||.|:|::...|||          |.:
Mouse   497 NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM 561

  Fly   759 VALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARF 823
            .....|:||...|.|.|||.:          ::.||||..||....:...:|...|..|||:...
Mouse   562 AFFRVDHGLMLTYFAAFEVFF----------EENLPKLFAHFKKNNLTADIYLIDWIFTLYSKSL 616

  Fly   824 PLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVM 888
            ||.....:.|||..||...||:.|:.:|.:.|..|.::||....: |...||:...:......:.
Mouse   617 PLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTRMDFIHSAQ-FLTRLPEDLPADEVFAAIS 680

  Fly   889 KQACERKIKKLKQYEEEFLLKKQHKERLEKE 919
            ....:.:.||..|     :|....|:..|.|
Mouse   681 TVQMQSRNKKWAQ-----VLSALQKDSREME 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	5/27 (19%)
		DUF3694	429..523	CDD:289256	16/93 (17%)
		TBC	650..858	CDD:214540	72/247 (29%)
		Phage_Gp23	<914..991	CDD:287621	2/6 (33%)
Tbc1d14	NP_001106833.1	ARGLU	<350..>392	CDD:373772	9/53 (17%)
Tbc1d14	NP_001106833.1	TBC	419..651	CDD:214540	72/247 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810