DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and tbc1d9b

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_009305930.1	Gene:	tbc1d9b / 100332046	-ID:	-	Length:	1218	Species:	Danio rerio

Alignment Length:	530	Identity:	120/530 - (22%)
Similarity:	216/530 - (40%)	Gaps:	116/530 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 VIETPVTIQSASEMRIMDHFMSKRP-MTLRFYLHLKRTEESNWKV-NSIDPSEEITEQPGHQQSS 573
            |:.:|::|.:.::|..:...:..|. :..|....|:||.:....| .|.:||      |....|.
Zfish   361 VLPSPLSISTKNKMTFLFANLKDRDFLVQRISDFLQRTPDGPCGVLQSENPS------PSTPPSP 419

  Fly   574 SLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDP-ILREW 637
            .:|.:           |..|.::...||         |.:....:.:...||..:|..| :.||.
Zfish   420 PVLSL-----------SESAQMQHYSPS---------LPTARKGLLQIYQQDVPEELGPKVTRER 464

  Fly   638 DSEK----------------RPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKE 686
            ..|:                |......||..|:||:||.::|...:..:..|..:..|...:.::
Zfish   465 MKEESWKIHFFEFGRGVCMYRTSKTRELVLNGIPESLRGELWLLFSGAQNEMATHPGYYGNLVEQ 529

  Fly   687 T--KCETV---IQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLL 746
            .  :|...   |:||:||:.|.|..|:  ..:|..||.:|..|||..:..:||||.::.:.:.||
Zfish   530 AMGRCTLATEEIERDLHRSMPEHHAFQ--NETGIAALRRVLTAYAYRNPGIGYCQAMNIVTSVLL 592

  Fly   747 LHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYA 811
            |:..||:||.:||||. :..|.|.|........:.....|.|.::.||.|:||....|:.:.:..
Zfish   593 LYCTEEEAFWLLVALC-ERMLPDYYNTRVVGALVDQGVFEELTRECLPLLYEHMQDLGVISTISL 656

  Fly   812 SQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPK 876
            | |||||:.:..|......::|.|..:|:.|:|||:   |::..:::.||              .
Zfish   657 S-WFLTLFLSVMPFDSAVLLVDCFFYEGIKVIFQVS---LAVLHANMDQL--------------L 703

  Fly   877 KCRSSSQARKVMKQACERKIKK-----------------------LKQYEEEFLLKKQHKERLEK 918
            .|....:|..::.:..:..:.|                       :..:|   |:|..:::....
Zfish   704 SCSDEGEAMTILGRYLDNVVNKQTVSPPIPHLHALLTSGNNPPPEIDVFE---LIKASYEKFGSL 765

  Fly   919 EAQIYEN-RFGEERRKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSE 982
            .|.:.|. ||.:..:.:|:..|...:.:.    ||:..|...|  |:|.:::.
Zfish   766 RADVIEQMRFKQRLKVIQSLEDTAKRSVV----RAIMTESAFT--IEELEELY------------ 812

  Fly   983 TLGKVMHMVS 992
            .|.|..|::|
Zfish   813 VLFKAKHIMS 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	3/11 (27%)
		TBC	650..858	CDD:214540	66/212 (31%)
		Phage_Gp23	<914..991	CDD:287621	15/77 (19%)
tbc1d9b	XP_009305930.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	300..395	CDD:270161	6/33 (18%)
		TBC	493..703	CDD:214540	68/230 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900