DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and evi5l

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_031753513.1	Gene:	evi5l / 100145757	XenbaseID:	XB-GENE-5723194	Length:	809	Species:	Xenopus tropicalis

Alignment Length:	717	Identity:	203/717 - (28%)
Similarity:	322/717 - (44%)	Gaps:	152/717 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   556 SIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSK 620
            ||.||:  :|.....:...|.|:...|......|.|:.|:...|.|..:|.|..||
Frog    29 SISPSD--SENLSPDELELLSKLEEQNRLLEADSKSLRSVTGPCRSTVTSPGPSPL--------- 82

  Fly   621 DCSQDTLDEWDPILREWD--SEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILI 683
              .||:.:.|..|:..|:  :.::.|.|..|:|.|:|...|..:||.|.|... |.:..:|..|:
Frog    83 --DQDSWELWGRIITHWEEWTRRKEKLLKELIRKGIPHHFRAMVWQMLCNATD-MPVKKQYADLL 144

  Fly   684 TKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLH 748
            ...:.||.:|:|||.||:|.|..||.....||:.||.|.|||::.|.|||||||.:||...||:.
Frog   145 RMSSPCEKLIRRDIARTYPEHDFFKGQDSLGQEGLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQ 209

  Fly   749 MPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQ 813
            ||||:||||.|.||.:|.||:|:|.....|.|.:||||.:::||||:|.:||.:....|.||||.
Frog   210 MPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQLEYMLQDQLPELSQHFRSHSFHTSMYASS 274

  Fly   814 WFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKC 878
            |||||:...|||.....:.|:|:.:||.|:|:|.:.||::.:::|.|||.||:.::|:..:|.:.
Frog   275 WFLTLFLTTFPLPVATRIFDIFIYEGLEVIFRVGMALLTVNQTELMQLDMEGMSQHFQKVIPHQF 339

  Fly   879 RSSSQARKVMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDAL 941
            .|...  |::.:|.:.|.  |::|:.|:|:...|..    |.|.||...|...|.|.::..|:.|
Frog   340 DSCPD--KLILKAYQVKYNPKRMKRLEKEYAAIKSK----EMEEQIEIKRLRTENRLLKQRIETL 398

  Fly   942 NK------------QLTSA----------KERAVEKEKKHTGI--IQEYKQII-QRQEQDMNTL- 980
            .|            |:|.|          :|.||.|::.:|..  :|..:.:| |.||:.|:..
Frog   399 EKESAALADRLIQGQVTRAQEAEENYAIKRELAVVKQQYYTATESLQNAQSLIRQLQEKQMDPRI 463

  Fly   981 -------------------SETLGKVMHMVSNCQDCQQQIDAGNDNAKSDDGKN----RGQTDAM 1022
                               :||||.:..|    ||  :.:|....|:...|..|    ..:..|:
Frog   464 TEEMVLHLESELEHSRLRETETLGALKEM----QD--KVVDLEKRNSALPDENNIALLHDEVQAL 522

  Fly  1023 RNANEHPLGPLDPLNAASQRIRE---------------------------LELELAQAKLAQVEA 1060
            |....|   .|..:....|::.|                           |:.|....:|.:|||
Frog   523 RKREAH---ALQAMREGQQQVTELRDRWQSLSSKGGGIWKDSPRKNTAVDLQDEAMSCRLREVEA 584

  Fly  1061 ECKNQDLNHQL-----SNTLSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRDNGSGGPMPSFQS 1120
            :.:.::|..::     ...:.|.|.:|      |.|....|:|::
Frog   585 QSETRELRQRVLILESQEVMHEKQLSR------LEKECKELRERL-------------------- 623

  Fly  1121 YMGQAPTTLSEASSPSGNQEYKTFAFASVGGSPKLPSKFQATKLRN-----SIDSLRNIVVPLDT 1180
               |:.|:.::|.....|::.:..|....    |...:..|.:||.     ::..:|..:..|:.
Frog   624 ---QSETSQNKALQSQMNEDKRRHAVTEC----KNKEEVMAVRLREADSMAAVAEMRQRIAELEI 681

  Fly  1181 GK 1182
            .|
Frog   682 QK 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	94/207 (45%)
		Phage_Gp23	<914..991	CDD:287621	28/121 (23%)
evi5l	XP_031753513.1	TBC	112..320	CDD:214540	94/208 (45%)
evi5l	XP_031753513.1	SMC_prok_B	<376..711	CDD:274008	66/350 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010