DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and tbc1d8b

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001107709.2	Gene:	tbc1d8b / 100101803	XenbaseID:	XB-GENE-923435	Length:	1119	Species:	Xenopus tropicalis

Alignment Length:	1108	Identity:	204/1108 - (18%)
Similarity:	359/1108 - (32%)	Gaps:	378/1108 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 DMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTP 406
            |.::.:||.|.|              :||..:|:....::.::....|.|...
Frog   105 DSSDDITSFVQG--------------KIRGLIAEEEKGSIIKEEDPEKFREAL------------ 143

  Fly   407 SNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQ-----PGGTGVATE--------SDS 458
                  |..|:|||         :.....|:..:|..|.:     .|...::|.        ..|
Frog   144 ------LKFEKCFG---------LPNQEKLVTYYSCSYWRGRVPCQGWLYLSTNFLSFYSFLLGS 193

  Fly   459 NAQQSSSWPYTIRAEWKAQ-------------EKAFEQLNLESSKTNLTV--AVDIVMRRIQEPV 508
            ..:...||....|.|..:.             |..:..:.|..::|.|.:  ..|..:||:.:..
Frog   194 EIKLIISWDEISRLEKTSTVLLTESIHVCCNGEDFYFSMFLHINETFLLMEQLADYAVRRLFDKE 258

  Fly   509 RF----VIETPVTI------QSASEMRIMDHFMSKRPMTLRF---------YLHL----KRTEES 550
            .|    ::..|:.|      ..|.......:|...:..||:.         :.||    |.....
Frog   259 TFENDPILNNPLQITKRGLESRAHSEHFRTYFRLPKEETLKEVHECFLWIPFAHLNSLGKMCISE 323

  Fly   551 NW------------------KVNSIDPSEEITEQ-PGHQQSSSLLKMGMNN-----LSRIVRSSS 591
            |:                  :|.|||.|:..|.. ....:...:|:.....     :.|:....:
Frog   324 NYVCFASHDGSLYSTIIPLREVVSIDKSDAATRAITFSTKERKILRFTDTKDFDALVDRLKARCT 388

  Fly   592 IAS------IEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTL----------------------- 627
            :.|      .|..|..|.....:|..::|.....|..|.:.|
Frog   389 VTSPHHTVYTETSCTEDQEELHEEHAMAGQSGARKTVSTEALMTVFHPQDAENLDTKMLKEKMKE 453

  Fly   628 DEWDPILREWD---SEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKE--- 686
            ..|..:..|..   |..|.|....||..|:||.||.::|...:.....|..|..|...|.::
Frog   454 QTWKILFTECGRGVSMFRTKKTRNLVVRGIPETLRGELWLLFSGAVNDMAANPGYYTEIVEKSLG 518

  Fly   687 --TKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHM 749
              |.....|:||:.|:.|.|..|:  ..:|..||.:|..|||..:.::||||.::.:.:.|||:.
Frog   519 TCTLATDEIERDLRRSLPEHPAFQ--SDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYA 581

  Fly   750 PEEDAFCVLVA----LMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMY 810
            .||:||.:|||    ::.||..|.:..|..:...     .|.|||:.||.|..|.|    :...:
Frog   582 KEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAV-----FEELIKEYLPLLTSHMT----DITFF 637

  Fly   811 AS---QWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRV 872
            :|   .|||||:.:..|:....:|:|.|..||:..:.|:.:.:|        ..:.|.:|
Frog   638 SSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLVVL--------DFNMEKLL----- 689

  Fly   873 TLPKKCRSSSQARKVMKQACERKIKK-----------------------------LKQYEEEF-L 907
                .|:..::|..::.:..:..:.|                             :::..|:| .
Frog   690 ----ACKDDAEAVTILNRFFDNVVNKDSPLPSSVQQAPTGAEGKPTGTKVDITDLIREANEKFGA 750

  Fly   908 LKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEY------ 966
            ::.:..|.:....::|..:..|...:.    :.:...|...|....:.|:.:....:|:
Frog   751 IRYEDVESMRSRNRLYVIQTLETTTRQ----NVVRVVLQDVKFSPADLEELYYLFKREHFLSCYW 811

  Fly   967 ---KQIIQRQEQDMNTLSETLGKVMHMVSNCQD--------CQQQIDAGNDNA---------KSD 1011
               ..|:...:..:..|.:     .|:  |||.        |.....|..|:.         ::.
Frog   812 TVNSSILSHHDPSLPYLEQ-----YHI--NCQQFRTLYHLLCPWAYSANADSLALWTFRLLDENM 869

  Fly  1012 DG--------------KNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQV---- 1058
            ||              .||..||.::                  .:.::.:..|..::..:
Frog   870 DGFINFKEFAFAFDVMYNRSFTDRLK------------------LLFKIHIPPAFTEVGSISPSE 916

  Fly  1059 EAECKNQDLNH--------QLSNTLSELQTNR--------------NSWQPWL------------ 1089
            ||:...:||.|        ...|...|:||..              ..||..|
Frog   917 EAKLSKEDLMHFSNLHITSPKENLSPEVQTKSPEKGRGKIDIQAYLKQWQDELARKEESIKDLPR 981

  Fly  1090 ---------SKTFNSL-----QEKVTTRG--------------GHRDNGSGGPMPSFQSYMGQAP 1126
                     |||..:|     :|::..|.              |.:.:.|..|..|    :.|.|
Frog   982 INQTQFIHFSKTLYNLFHGDPEEELLYRAIAAVTNLLLRMEEVGRKLHISSSPCKS----LAQEP 1042

  Fly  1127 -------TTLSEASS---------PSGNQEYKTFAF----ASVGGSPKLPSKFQ-ATKLRNSIDS 1170
                   ||..|.:|         ||......:|||    ||:...|.|...|: .|.|::.:::
Frog  1043 CTDTRETTTQGEDTSQATENTVLQPSKENTEWSFAFEQILASLLNEPTLVRFFEKTTDLKSKLEN 1107

  Fly  1171 LRN 1173
            .|:
Frog  1108 TRS 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	21/131 (16%)
		TBC	650..858	CDD:214540	67/219 (31%)
		Phage_Gp23	<914..991	CDD:287621	10/85 (12%)
tbc1d8b	NP_001107709.2	PH-GRAM1_TBC1D8B	155..253	CDD:275419	15/97 (15%)
		PH-GRAM2_TBC1D8B	295..387	CDD:270159	14/91 (15%)
		TBC	481..689	CDD:214540	67/226 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000