DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7182 and hspa8

DIOPT Version :9

Sequence 1:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001103873.1	Gene:	hspa8 / 573376	ZFINID:	ZDB-GENE-990415-92	Length:	649	Species:	Danio rerio

Alignment Length:	524	Identity:	134/524 - (25%)
Similarity:	237/524 - (45%)	Gaps:	75/524 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67
            |..||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.....: .|..||.::|..|...|
Zfish     5 PAVGIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERL-IGDAAKNQVAMNPTNTV 67

  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVTKDLSAYQV 130
                                        ||.:.|:.|.  :..|.||.:.....|: .|.|..:|
Zfish    68 ----------------------------FDAKRLIGRRFDDGVVQSDMKHWPFNVI-NDNSRPKV 103

  Fly   131 TVE----------------LLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAG 179
            .||                :|....|:|..|.  |:....||:::|:|:..|..:...||...:|
Zfish   104 QVEYKGESKSFYPEEISSMVLTKMKEIAEAYL--GKTVSNAVITVPAYFNDSQRQATKDAGTISG 166

  Fly   180 FHVAQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGG 244
            .:|.:||.|||||.:.|.: :::....|:||....||...|::..::::|:|...:|.|...:||
Zfish   167 LNVLRIINEPTAAAIAYGL-DKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGG 230

  Fly   245 RQFTEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNA 309
            ..|...:|.....||:||:|.|..:::|:|.::|||....|..|::.....:.||||.:|:|:..
Zfish   231 EDFDNRMVNHFITEFKRKHKKDISDNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYT 295

  Fly   310 QMSRARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDA 374
            .::|||||.|...:....:..:.:.:..|:.:.   ::|.||||:|.:.:|||:|..:...|...
Zfish   296 SITRARFEELNADLFRGTLDPVEKALRDAKMDK---AQIHDIVLVGGSTRIPKIQKLLQDYFNGK 357

  Fly   375 KLHNSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWH------GNDESNA--KL 431
            :|:.|.:.||.||.|.|.||..|.....:.:          .||.:..      |.:.:..  .:
Zfish   358 ELNKSINPDEAVAYGAAVQAAILSGDKSENV----------QDLLLLDVTPLSLGIETAGGVMTV 412

  Fly   432 VLGRGSVLPAKIRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--EDGLYQLEVE 494
            ::.|.:.:|.|...:.....:.:...:.:.....:..|.::.:|.:...:.||  ..|:.|:||.
Zfish   413 LIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVT 477

  Fly   495 VDVD 498
            .|:|
Zfish   478 FDID 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	114/406 (28%)
hspa8	NP_001103873.1	HSP70	1..614	CDD:331774	134/524 (26%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		118/417 (28%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		14/88 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810