DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7182 and HSPA14

DIOPT Version :9

Sequence 1:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_057383.2	Gene:	HSPA14 / 51182	HGNCID:	29526	Length:	509	Species:	Homo sapiens

Alignment Length:	525	Identity:	159/525 - (30%)
Similarity:	246/525 - (46%)	Gaps:	86/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70
            |:.:|.::.|:| |..||:|.|:||..||||:.|.:.:....|| .||.|||.........|...
Human     5 GVHLGCTSACVA-VYKDGRAGVVANDAGDRVTPAVVAYSENEEI-VGLAAKQSRIRNISNTVMKV 67

  Fly    71 FQLL-------QPKEELTEEKLSSALREIPCDFDKEELVF----RMEHTVPSDREDQDDRVVTKD 124
            .|:|       |.::.:.|.|         |      ||.    ::.:.:.:..|       ||.
Human    68 KQILGRSSSDPQAQKYIAESK---------C------LVIEKNGKLRYEIDTGEE-------TKF 110

  Fly   125 LSAYQVTVELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEP 189
            ::...|...:.....|.||.  ..|..|...|:::|..:.......|.:||:.|||:|.::|.||
Human   111 VNPEDVARLIFSKMKETAHS--VLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEP 173

  Fly   190 TAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQF 254
            :||:|.|.||::....:.::|..|.||....::...|.:|::..|:|.....|||..|||.|.|:
Human   174 SAALLAYGIGQDSPTGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQY 238

  Fly   255 ICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMSRARFESL 319
            :..||:|.:|.|...:.|::.|:..:|...||.|:|:.|...::|||.:|.|::..:||||||.|
Human   239 LASEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELL 303

  Fly   320 IQPVINNLIQQLGECVEQAQKEHPGLS--KIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSA 382
            ..|:.|..|:.:...::|     .|.:  .|:.:||.|.:.:|||||..:...||..:|.||...
Human   304 CSPLFNKCIEAIRGLLDQ-----NGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPP 363

  Fly   383 DEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFI--------WHGNDESNAK---LVLGRG 436
            |||:.||.|.:|..||.       ||.  ::.||.|.|        ..|.|||.|.   ::...|
Human   364 DEVIPIGAAIEAGILIG-------KEN--LLVEDSLMIECSARDILVKGVDESGASRFTVLFPSG 419

  Fly   437 SVLPAKIRISL--PQS--------EEGKGDDVSKAAASF---------KLRTGESEILARLPDST 482
            :.|||:.:.:|  |.|        .|..|.:.:|....|         |...|..:|||.|   |
Human   420 TPLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVL---T 481

  Fly   483 IPEDG 487
            :..||
Human   482 MKRDG 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	125/400 (31%)
HSPA14	NP_057383.2	HSPA14-like_NBD	2..376	CDD:212680	125/401 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384154at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810