DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7182 and HSPA5

DIOPT Version :10

Sequence 1:NP_648212.1 Gene:CG7182 / 38944 FlyBaseID:FBgn0035878 Length:513 Species:Drosophila melanogaster
Sequence 2:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens


Alignment Length:534 Identity:124/534 - (23%)
Similarity:226/534 - (42%) Gaps:102/534 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70
            ||.:|.:..|:. |..:|:.|:|||.||:|::.:.:.:....|...|..||.::.:.|...|   
Human    32 GIDLGTTYSCVG-VFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTV--- 92

  Fly    71 FQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVTKDLSAY----- 128
                                     ||.:.|:.|.  :.:|..|.:....:||.|....|     
Human    93 -------------------------FDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDI 132

  Fly   129 -----------QVTVELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHV 182
                       :::..:|....|.|..|.  |::...||:::|:|:..:..:...||...||.:|
Human   133 GGGQTKTFAPEEISAMVLTKMKETAEAYL--GKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNV 195

  Fly   183 AQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQF 247
            .:||.|||||.:.|  |.::.|..:::|....||...|::..::.||:|..:||.|...:||..|
Human   196 MRIINEPTAAAIAY--GLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDF 258

  Fly   248 TEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMS 312
            .:.:::...:.:::|...|..:..|:|.|:|......|..|::....::.|:|..:|.|::..::
Human   259 DQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLT 323

  Fly   313 RARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLH 377
            ||:||.|...:..:.::.:.:.:|.:..:.   |.||:|||:|.:.:|||:|..|...|...:..
Human   324 RAKFEELNMDLFRSTMKPVQKVLEDSDLKK---SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPS 385

  Fly   378 NSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVL--------- 433
            ...:.||.||.|.|.||..|                         ..|:....|||         
Human   386 RGINPDEAVAYGAAVQAGVL-------------------------SGDQDTGDLVLLDVCPLTLG 425

  Fly   434 ------------GRGSVLPAKIRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP-- 484
                        .|.:|:|.|.......:.:.:.....|.....:..|.::.:|.....:.||  
Human   426 IETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPA 490

  Fly   485 EDGLYQLEVEVDVD 498
            ..|:.|:||..::|
Human   491 PRGVPQIEVTFEID 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7182NP_648212.1 ASKHA_ATPase-like 5..394 CDD:483947 103/405 (25%)
HSPA5NP_005338.1 Required for interaction with ELAPOR1. /evidence=ECO:0000269|PubMed:26045166 1..80 15/48 (31%)
HSP70 30..635 CDD:394970 124/534 (23%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 40/158 (25%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 3/9 (33%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 12/79 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654
Prevents secretion from ER. /evidence=ECO:0000255 651..654
Blue background indicates that the domain is not in the aligned region.

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