Protein Alignment CG7182 and HSPA4

DIOPT Version :10

• Sequence 1: NP_648212.1
• Gene: CG7182 / 38944
• FlyBaseID: FBgn0035878
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_002145.3
• Gene: HSPA4 / 3308
• HGNCID: 5237
• Length: 840
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 120/521 - (23%)
• Similarity: 210/521 - (40%)
• Gaps: 74/521 - (14%)

  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVA-- 68
            ||.:|..:..:|..||.| .|.|||:..||.:.||:.: |......|..||.::.:..:..|.
Human     5 GIDLGFQSCYVAVARAGG-IETIANEYSDRCTPACISF-GPKNRSIGAAAKSQVISNAKNTVQGF 67

  Fly    69 ---HSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQV 130
               |......|..|..:..|:..:.::|......::.:..|.               ::.:..||
Human    68 KRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEE---------------RNFTTEQV 117

  Fly   131 TVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAV 193
            |..||....|.|...    .:.|:  .|:|:|.:|..:..:.:.||.|.||.:..:::.|.||..
Human   118 TAMLLSKLKETAESV----LKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVA 178

  Fly   194 LGYSIGEEQ----TEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQF 254
            |.|.|.::.    .|:.|:|:.:..|.....::..:...|....|||.....:|||:|.|.||..
Human   179 LAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNH 243

  Fly   255 ICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPS-TQLYIDSLMDGVDYNAQMSRARFES 318
            .||||.:|||||.....|::.::.......|.:::...| ..|.|:..|:.||.:..|:|.:|..
Human   244 FCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLE 308

  Fly   319 LIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSAD 383
            :...::..:...|...:||.:.:...:..::   ::|...:||.::..: ::|...:|..:.:||
Human   309 MCNDLLARVEPPLRSVLEQTKLKKEDIYAVE---IVGGATRIPAVKEKI-SKFFGKELSTTLNAD 369

  Fly   384 EVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLGRGSVLPAKIRISLP 448
            |.|..|||.|...|....:.:.....|.|                         ..|..:|.:.|
Human   370 EAVTRGCALQCAILSPAFKVREFSITDVV-------------------------PYPISLRWNSP 409

  Fly   449 QSEEGKGD----------DVSKAAASFKLRTGESEILARLP-DSTIPEDGLYQLEVEVDVDDKDG 502
             :|||..|          ..||....::......|.....| |...|:..:.|..|:......||
Human   410 -AEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDG 473

  Fly   503 N 503
            :
Human   474 S 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_648212.1	ASKHA_ATPase-like	5..394	CDD:483947	99/399 (25%)
HSPA4	NP_002145.3	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	100/401 (25%)
		PTZ00121	<499..743	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..840