DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7182 and Hspa5

DIOPT Version :9

Sequence 1:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_037215.1	Gene:	Hspa5 / 25617	RGDID:	2843	Length:	654	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	124/534 - (23%)
Similarity:	226/534 - (42%)	Gaps:	102/534 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70
            ||.:|.:..|:. |..:|:.|:|||.||:|::.:.:.:....|...|..||.::.:.|...|
  Rat    32 GIDLGTTYSCVG-VFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTV--- 92

  Fly    71 FQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVTKDLSAY----- 128
                                     ||.:.|:.|.  :.:|..|.:....:||.|....|
  Rat    93 -------------------------FDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDI 132

  Fly   129 -----------QVTVELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHV 182
                       :::..:|....|.|..|.  |::...||:::|:|:..:..:...||...||.:|
  Rat   133 GGGQTKTFAPEEISAMVLTKMKETAEAYL--GKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNV 195

  Fly   183 AQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQF 247
            .:||.|||||.:.|  |.::.|..:::|....||...|::..::.||:|..:||.|...:||..|
  Rat   196 MRIINEPTAAAIAY--GLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDF 258

  Fly   248 TEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMS 312
            .:.:::...:.:::|...|..:..|:|.|:|......|..|::....::.|:|..:|.|::..::
  Rat   259 DQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLT 323

  Fly   313 RARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLH 377
            ||:||.|...:..:.::.:.:.:|.:..:.   |.||:|||:|.:.:|||:|..|...|...:..
  Rat   324 RAKFEELNMDLFRSTMKPVQKVLEDSDLKK---SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPS 385

  Fly   378 NSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVL--------- 433
            ...:.||.||.|.|.||..|                         ..|:....|||
  Rat   386 RGINPDEAVAYGAAVQAGVL-------------------------SGDQDTGDLVLLDVCPLTLG 425

  Fly   434 ------------GRGSVLPAKIRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP-- 484
                        .|.:|:|.|.......:.:.:.....|.....:..|.::.:|.....:.||
  Rat   426 IETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPA 490

  Fly   485 EDGLYQLEVEVDVD 498
            ..|:.|:||..::|
  Rat   491 PRGVPQIEVTFEID 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	103/405 (25%)
Hspa5	NP_037215.1	Required for interaction with KIAA1324. /evidence=ECO:0000250\|UniProtKB:P11021	1..80		15/48 (31%)
		HSPA5-like_NBD	28..403	CDD:212681	104/406 (26%)
		HSP70	30..635	CDD:278441	124/534 (23%)
		Nucleotide-binding (NBD). /evidence=ECO:0000250\|UniProtKB:P11021	125..280		40/158 (25%)
		Interdomain linker. /evidence=ECO:0000250\|UniProtKB:G3I8R9	409..419		3/9 (33%)
		Substrate-binding (SBD). /evidence=ECO:0000250\|UniProtKB:P11021	420..500		12/79 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..654
		Prevents secretion from ER	651..654
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900