DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7182 and Hspa9

DIOPT Version :9

Sequence 1:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_034611.2	Gene:	Hspa9 / 15526	MGIID:	96245	Length:	679	Species:	Mus musculus

Alignment Length:	509	Identity:	127/509 - (24%)
Similarity:	227/509 - (44%)	Gaps:	56/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIKIGNSTLCIAHVRADGK-AEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAH 69
            ||.:|.:..|:|.:  :|| |:|:.|.:|.|.:.:.:.:....|...|:.||::....|......
Mouse    57 GIDLGTTNSCVAVM--EGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYA 119

  Fly    70 SFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQVTVEL 134
            :.:|:..:.:  :.::....:.:|         |::   |.:...|.......|..|..|:...:
Mouse   120 TKRLIGRRYD--DPEVQKDTKNVP---------FKI---VRASNGDAWVEAHGKLYSPSQIGAFV 170

  Fly   135 LRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAVLGYSIG 199
            |....|.|..|.  |..|..||:::|:|:..|..:...||.|.:|.:|.::|.|||||.|.|.:.
Mouse   171 LMKMKETAENYL--GHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLD 233

  Fly   200 EEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQFICEEFRRKYK 264
            :.:.   :.:.....||...||:...:|.|:|...:|.|...:||..|.:||::.|.:||:|:..
Mouse   234 KSED---KVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETG 295

  Fly   265 LDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSL-MDG---VDYNAQMSRARFESLIQPVIN 325
            :|..:...::.::|.||...|..|::...|.:.:..| ||.   ...|.:::||:||.::..:|.
Mouse   296 VDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIK 360

  Fly   326 NLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGC 390
            ..|   ..|.:..|......|.|.:::|:|...::||:|..|...|..|. ..:.:.||.||||.
Mouse   361 RTI---APCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAP-SKAVNPDEAVAIGA 421

  Fly   391 ARQA---------VCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLGRGSVLPAKIRIS 446
            |.|.         |.|:|.....|..|     ....:|         .||: .|.:.:|.|....
Mouse   422 AIQGGVLAGDVTDVLLLDVTPLSLGIE-----TLGGVF---------TKLI-NRNTTIPTKKSQV 471

  Fly   447 LPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--EDGLYQLEVEVDVD 498
            ...:.:|:.....|.....:...|::::|.:.....||  ..|:.|:||..|:|
Mouse   472 FSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDID 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	103/392 (26%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250\|UniProtKB:P38646	1..432		104/399 (26%)
		dnaK	52..673	CDD:234715	127/509 (25%)
		HSPA9-like_NBD	52..428	CDD:212683	104/395 (26%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250\|UniProtKB:P38646	432..679		23/109 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900