DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7182 and Hspa2

DIOPT Version :9

Sequence 1:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001002012.1	Gene:	Hspa2 / 15512	MGIID:	96243	Length:	633	Species:	Mus musculus

Alignment Length:	530	Identity:	135/530 - (25%)
Similarity:	238/530 - (44%)	Gaps:	85/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67
            |..||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.....: .|..||.::|..|...:
Mouse     6 PAIGIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERL-IGDAAKNQVAMNPTNTI 68

  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVT-------- 122
                                        ||.:.|:.|.  :.||.||.:....|||:
Mouse    69 ----------------------------FDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQ 105

  Fly   123 -------KDLSAYQVTVELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGF 180
                   |.....:::..:|....|:|..|.  |.:...||:::|:|:..|..:...||....|.
Mouse   106 VEYKGEMKTFFPEEISSMVLTKMKEIAEAYL--GGKVQSAVITVPAYFNDSQRQATKDAGTITGL 168

  Fly   181 HVAQIITEPTAAVLGYSI-------GEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFG 238
            :|.:||.|||||.:.|.:       ||      ::||....||...|::..::::|:|...:|.|
Mouse   169 NVLRIINEPTAAAIAYGLDKKGCAGGE------KNVLIFDLGGGTFDVSILTIEDGIFEVKSTAG 227

  Fly   239 PFPIGGRQFTEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMD 303
            ...:||..|...:|..:.|||:||:|.|...::|:|.::|||....|..|::.....:.||||.:
Mouse   228 DTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYE 292

  Fly   304 GVDYNAQMSRARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVG 368
            |||:...::|||||.|...:....::.:.:.:..|:.:.   .:|.:|||:|.:.:|||:|..:.
Mouse   293 GVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDK---GQIQEIVLVGGSTRIPKIQKLLQ 354

  Fly   369 ARFPDAKLHNSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWH------GNDES 427
            ..|...:|:.|.:.||.||.|.|.||..||....:.:          .||.:..      |.:.:
Mouse   355 DFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENV----------QDLLLLDVTPLSLGIETA 409

  Fly   428 NAKL--VLGRGSVLPAKIRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--EDGL 488
            ...:  ::.|.:.:|.|...:.....:.:...:.:.....:..|.::.:|.:...:.||  ..|:
Mouse   410 GGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGV 474

  Fly   489 YQLEVEVDVD 498
            .|:||..|:|
Mouse   475 PQIEVTFDID 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	114/412 (28%)
Hspa2	NP_001002012.1	PTZ00009	2..615	CDD:240227	135/530 (25%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..389		119/423 (28%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	397..512		14/88 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810