DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7182 and Hsph1

DIOPT Version :9

Sequence 1:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_006504979.1	Gene:	Hsph1 / 15505	MGIID:	105053	Length:	877	Species:	Mus musculus

Alignment Length:	521	Identity:	119/521 - (22%)
Similarity:	214/521 - (41%)	Gaps:	91/521 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GASEIECGLTAKQKMANRPRQAVAHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTV 109
            |:.....|:.||.:........|: ||:....:          |..:.....:||.|.:.:   |
Mouse    61 GSKNRTIGVAAKNQQITHANNTVS-SFKRFHGR----------AFNDPFIQKEKENLSYDL---V 111

  Fly   110 PSDREDQDDRVVTKD----LSAYQVTVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAY 168
            |........:|:..|    .|..|:|..||....|.|.    :..:.|:  .|:|:||::..:..
Mouse   112 PMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAE----NNLKKPVTDCVISVPSFFTDAER 172

  Fly   169 KLLADAAQTAGFHVAQIITEPTAAVLGYSIGEEQ----TEQRRHVLTIKCGGLYSDIAFYSVQNG 229
            :.:.||||..|.:..:::.:.||..|.|.|.::.    .|:.|.|:.:..|.....::..:...|
Mouse   173 RSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKG 237

  Fly   230 LFVQLAT-FGPFPIGGRQFTEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHIL----T 289
            ....|.| |.|| :||:.|.|.||:..|.||:.|||||.....|::.::.......|.::    |
Mouse   238 KLKVLGTAFDPF-LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNST 301

  Fly   290 TMPSTQLYIDSLMDGVDYNAQMSRARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLL 354
            .:|   |.|:..|:..|.:.:|:|::||.|...::..:...|...:.|.|.:...:|.|:   ::
Mouse   302 DLP---LNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIE---IV 360

  Fly   355 GATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLF 419
            |...:||.::..: |:|....:..:.:|||.||.|||.|...|....:.:.....|.|.....|
Mouse   361 GGATRIPAVKERI-AKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISL- 423

  Fly   420 IWHGNDESNAKL--VLGRGSVLP-AKI-------------------RISLPQSEEGK-------- 454
            :|:.:.|....:  |..|....| :|:                   .:..|:::.|:
Mouse   424 VWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSA 488

  Fly   455 GDDVSKAAASFKLRT--------GESEILARLPDSTIPEDGLYQLEVEVDV--------DDKDGN 503
            ..|..|:....|:|.        ..:.::.::|  |..||| ..||.:::.        .|.|.|
Mouse   489 QKDGEKSRVKVKVRVNTHGIFTISTASMVEKVP--TEEEDG-SSLEADMECPNQRPTESSDVDKN 550

  Fly   504 V 504
            :
Mouse   551 I 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	92/363 (25%)
Hsph1	XP_006504979.1	NBD_sugar-kinase_HSP70_actin	56..403	CDD:388382	93/367 (25%)
		FtsN	<537..>620	CDD:225629	3/15 (20%)
		DUF4127	<673..761	CDD:379257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900