Protein Alignment CG7182 and Hspa5

DIOPT Version :9

• Sequence 1: NP_001286979.1
• Gene: CG7182 / 38944
• FlyBaseID: FBgn0035878
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001156906.1
• Gene: Hspa5 / 14828
• MGIID: 95835
• Length: 655
• Species: Mus musculus
• Alignment Length: 534
• Identity: 124/534 - (23%)
• Similarity: 226/534 - (42%)
• Gaps: 102/534 - (19%)

  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70
            ||.:|.:..|:. |..:|:.|:|||.||:|::.:.:.:....|...|..||.::.:.|...|
Mouse    33 GIDLGTTYSCVG-VFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTV--- 93

  Fly    71 FQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVTKDLSAY----- 128
                                     ||.:.|:.|.  :.:|..|.:....:||.|....|
Mouse    94 -------------------------FDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDI 133

  Fly   129 -----------QVTVELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHV 182
                       :::..:|....|.|..|.  |::...||:::|:|:..:..:...||...||.:|
Mouse   134 GGGQTKTFAPEEISAMVLTKMKETAEAYL--GKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNV 196

  Fly   183 AQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQF 247
            .:||.|||||.:.|  |.::.|..:::|....||...|::..::.||:|..:||.|...:||..|
Mouse   197 MRIINEPTAAAIAY--GLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDF 259

  Fly   248 TEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMS 312
            .:.:::...:.:::|...|..:..|:|.|:|......|..|::....::.|:|..:|.|::..::
Mouse   260 DQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLT 324

  Fly   313 RARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLH 377
            ||:||.|...:..:.::.:.:.:|.:..:.   |.||:|||:|.:.:|||:|..|...|...:..
Mouse   325 RAKFEELNMDLFRSTMKPVQKVLEDSDLKK---SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPS 386

  Fly   378 NSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVL--------- 433
            ...:.||.||.|.|.||..|                         ..|:....|||
Mouse   387 RGINPDEAVAYGAAVQAGVL-------------------------SGDQDTGDLVLLDVCPLTLG 426

  Fly   434 ------------GRGSVLPAKIRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP-- 484
                        .|.:|:|.|.......:.:.:.....|.....:..|.::.:|.....:.||
Mouse   427 IETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPA 491

  Fly   485 EDGLYQLEVEVDVD 498
            ..|:.|:||..::|
Mouse   492 PRGVPQIEVTFEID 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	103/405 (25%)
Hspa5	NP_001156906.1	Required for interaction with KIAA1324. /evidence=ECO:0000250|UniProtKB:P11021	1..81		15/48 (31%)
		HSP70	31..636	CDD:365808	124/534 (23%)
		Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021	126..281		40/158 (25%)
		Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9	410..420		3/9 (33%)
		Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021	421..501		12/79 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655
		Prevents secretion from ER	652..655

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900