DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-alpha50 and POLA3

DIOPT Version :9

Sequence 1:	NP_523972.2	Gene:	DNApol-alpha50 / 38942	FlyBaseID:	FBgn0011762	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_199003.5	Gene:	POLA3 / 834193	AraportID:	AT5G41880	Length:	451	Species:	Arabidopsis thaliana

Alignment Length:	432	Identity:	175/432 - (40%)
Similarity:	238/432 - (55%)	Gaps:	44/432 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PEVLQDM----LPVYYRRLFPHLPFYRWLSYG------SSEDAIFSNREISFTLQDDIYIRYLCF 79
            |::..|.    |.:||..|||:...::|||||      ..::..|..||.||||::|:|:||..|
plant    20 PKIENDFNVHYLRIYYGNLFPYTDIHKWLSYGHDGKHPGCDEYYFGRREFSFTLENDVYLRYKSF 84

  Fly    80 DTQAELEKEICSRNPIKIDIGPVMHSKP-KNHRSIPGG---LTPVQRELVFDIDMTDYDEVRTCC 140
            ...:.:|..|.|..|.|||||.|....| |.|.....|   .|||:||||||||:||||:||.||
plant    85 KNASLMEAAIKSNFPYKIDIGAVYSVDPDKRHAYAQSGTNLFTPVERELVFDIDITDYDDVRYCC 149

  Fly   141 SGAGVCLKCWKFMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAE 205
            |||.||.|||..|.:|.:|:|.:|||||||:||:|:||||||:||||||.:||.|....|.||||
plant   150 SGADVCSKCWPLMTVAIKVIDTSLREDFGFKHILWVFSGRRGVHCWVCDAKARRLTNEQRSAVAE 214

  Fly   206 YLNIITYASFAGGNSPRCSMGDRPHHSL-----KRALKIVEPMFEEIVLEDQNLFGTPKGVTKLL 265
            |..:..      ||.......|...|||     :..:..::..||..:...|::|.:.:...|:|
plant   215 YFRVYK------GNENNAKKVDLMGHSLHPFLARSYVDFIKSFFEGELQATQSIFSSKEKYEKIL 273

  Fly   266 NMVHDD----AARGELESYMQKNLEDGAHSRLVWESFIKYANSMRTSTTSAWSRKLKNIVAEIQL 326
            .|:.|:    ..||:.|:..:.:|.:.|.|.|.||...|...|.|....|     |:..|.||..
plant   274 GMITDEDIQADLRGKWENSARSSLSEEATSLLRWEQLKKALQSKRNKALS-----LRTCVEEIVF 333

  Fly   327 GLLYPRLDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEINAFDDK 391
            ...|||:|:.|::..|||||||||:||.||:||||...:...:|||..|||::||:.|||:
plant   334 TFTYPRIDLEVSKQMNHLLKAPFCVHPKTGRVCVPIDPNNCDEFDPLAVPTLSQLIEEINS---- 394

  Fly   392 SKSYMEAPEDKSRIKDHKKTSMFKGVVVF-EEFLRKLERSQK 432
            ....|:..:|     |...:.:.|.:..| ..||..|.:|.|
plant   395 GGLRMDVDDD-----DSDSSLLGKSIKFFRSSFLEPLLKSCK 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha50	NP_523972.2	AE_Prim_S	41..372	CDD:240130	148/349 (42%)
POLA3	NP_199003.5	AE_Prim_S	40..379	CDD:240130	148/349 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	209	1.000	Domainoid score	I805
eggNOG	1	0.900	-	-		E1_COG1467
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H730
Inparanoid	1	1.050	304	1.000	Inparanoid score	I772
OMA	1	1.010	-	-		QHG54298
OrthoDB	1	1.010	-	-		D1346165at2759
OrthoFinder	1	1.000	-	-		FOG0004166
OrthoInspector	1	1.000	-	-		oto4196
orthoMCL	1	0.900	-	-		OOG6_101221
Panther	1	1.100	-	-	LDO	PTHR10536
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2917
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840