DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha50 and PRIM1

DIOPT Version :9

Sequence 1:	NP_523972.2	Gene:	DNApol-alpha50 / 38942	FlyBaseID:	FBgn0011762	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_000937.1	Gene:	PRIM1 / 5557	HGNCID:	9369	Length:	420	Species:	Homo sapiens

Alignment Length:	433	Identity:	181/433 - (41%)
Similarity:	263/433 - (60%)	Gaps:	36/433 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VHAYNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAE 84
            :..::|..|.::|.:|||||||:..:||||:||......|.:||.||||:|||||||..|:.|::
Human     1 METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSD 65

  Fly    85 LEKEICSRNPIKIDIGPVMHSKPKNHRSIP-GGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLK 148
            ||||:...||.|||||.|...:|..|.::. |.....::||||||||||||:||.|||.|.:|.|
Human    66 LEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPK 130

  Fly   149 CWKFMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYA 213
            ||..|.:|.|::|.||:|||||:|.:|::|||||:||||||...|.|....|..:.|||:::
Human   131 CWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLV--- 192

  Fly   214 SFAGGN--SPRCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMV----HDDA 272
              .||.  ..:..:.::.|..:::::.|::..|||..|.:|::....:...|:|.:|    ||
Human   193 --KGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHD-- 253

  Fly   273 ARGELESYMQKNLEDGAHSRLV-WESFIK----YANSMRTSTTSAWSRKLKNIVAEIQLGLLYPR 332
               ||:...||     :|:.|. ||...|    |.|:::......|      :..||.|...:||
Human   254 ---ELQQSFQK-----SHNSLQRWEHLKKVASRYQNNIKNDKYGPW------LEWEIMLQYCFPR 304

  Fly   333 LDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEINAF--DDKSKSY 395
            |||||::|.|||||:||.:||.||::.||..:..|.:|||.|||||:.:..|::|.  :::.|..
Human   305 LDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAISTNEEEKEE 369

  Fly   396 MEAPED-KSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQ 437
            .||..| |.|.:|:||||:...|.|||.||..|::|:|...|:
Human   370 NEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLK 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha50	NP_523972.2	AE_Prim_S	41..372	CDD:240130	142/342 (42%)
PRIM1	NP_000937.1	AE_Prim_S	22..344	CDD:240130	142/342 (42%)
		Zinc knuckle motif	121..131		5/9 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..382		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147246
Domainoid	1	1.000	191	1.000	Domainoid score	I3251
eggNOG	1	0.900	-	-		E1_COG1467
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H730
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2351
Isobase	1	0.950	-	0	Normalized mean entropy	S1232
OMA	1	1.010	-	-		QHG54298
OrthoDB	1	1.010	-	-		D1346165at2759
OrthoFinder	1	1.000	-	-		FOG0004166
OrthoInspector	1	1.000	-	-		oto89946
orthoMCL	1	0.900	-	-		OOG6_101221
Panther	1	1.100	-	-	LDO	PTHR10536
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2917
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720