DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-alpha50 and prim1

DIOPT Version :9

Sequence 1:	NP_523972.2	Gene:	DNApol-alpha50 / 38942	FlyBaseID:	FBgn0011762	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_958856.1	Gene:	prim1 / 30440	ZFINID:	ZDB-GENE-990603-6	Length:	425	Species:	Danio rerio

Alignment Length:	426	Identity:	181/426 - (42%)
Similarity:	255/426 - (59%)	Gaps:	25/426 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAELEK 87
            |:...|.|:||:|||||||...::||||||......|.|||.||||:||||:||..|.:|.||||
Zfish     6 YDSACLPDLLPLYYRRLFPFSQYFRWLSYGGVSKNYFQNREFSFTLKDDIYVRYQSFSSQNELEK 70

  Fly    88 EICSRNPIKIDIGPVMHSKPKNHRSIPGG-LTPVQRELVFDIDMTDYDEVRTCCSGAGVCLKCWK 151
            |:....|.|||||.|...:|..|.::..| ...:::||||||||||||:||.|||.|.:|.|||.
Zfish    71 EMQKMVPYKIDIGAVYSHRPSQHNTVKSGTFQALEKELVFDIDMTDYDDVRRCCSAADICSKCWT 135

  Fly   152 FMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYASFA 216
            .|.:|.|:||.||||||||.|::|::|||||:||||||..||.|....|.||||||:::     .
Zfish   136 LMTIAIRILDRALREDFGFHHLLWVYSGRRGVHCWVCDDAARKLSVAARSAVAEYLSLV-----K 195

  Fly   217 GGNSP--RCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMVHDDAARGELES 279
            ||...  :..:.|..|..:.|:|.:||..|.:..:.||::.|..:.|.|:|.::.:|..: :|..
Zfish   196 GGEETLRKVVLSDPIHPFISRSLSVVEHYFPQYAIVDQDILGNKESVDKVLALLPEDIKK-DLIE 259

  Fly   280 YMQKNLEDGAHSRLVWESFIKYANSMRTSTTSAWSRKLKNIVAEIQLGLLYPRLDINVTRGFNHL 344
            |.|.:.|....    |:...:..:..::|:........|    ||.|...|||||:||::|.|||
Zfish   260 YYQNHKEPMKR----WDRLRQLVDHKKSSSKKGGQYYDK----EIMLQYCYPRLDVNVSKGVNHL 316

  Fly   345 LKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEI------NAFDD--KSKSYMEAPED 401
            ||:||.:||.||::.||..:..:..|||..||||:.:..|:      .|.|:  |.|...:...:
Zfish   317 LKSPFSVHPKTGRISVPIDLKELDTFDPFEVPTISLICEELEKPRADEAEDEDVKDKENEQEAAE 381

  Fly   402 KSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQ 437
            :.||:|:|:||:.|.|.|.:.||..:.||:|...|:
Zfish   382 RRRIRDYKRTSLAKYVKVLDRFLDSMARSRKGEMLK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha50	NP_523972.2	AE_Prim_S	41..372	CDD:240130	144/333 (43%)
prim1	NP_958856.1	AE_Prim_S	24..344	CDD:240130	144/333 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580758
Domainoid	1	1.000	200	1.000	Domainoid score	I2996
eggNOG	1	0.900	-	-		E1_COG1467
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H730
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2315
OMA	1	1.010	-	-		QHG54298
OrthoDB	1	1.010	-	-		D1346165at2759
OrthoFinder	1	1.000	-	-		FOG0004166
OrthoInspector	1	1.000	-	-		oto40642
orthoMCL	1	0.900	-	-		OOG6_101221
Panther	1	1.100	-	-	LDO	PTHR10536
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R980
SonicParanoid	1	1.000	-	-		X2917
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800