DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-alpha50 and Prim1

DIOPT Version :9

Sequence 1:	NP_523972.2	Gene:	DNApol-alpha50 / 38942	FlyBaseID:	FBgn0011762	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_032947.1	Gene:	Prim1 / 19075	MGIID:	97757	Length:	417	Species:	Mus musculus

Alignment Length:	432	Identity:	179/432 - (41%)
Similarity:	260/432 - (60%)	Gaps:	43/432 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAELEK 87
            ::|..|.::|.:|||||||:..:||||:||......|.:||.||||:|||||||..|:.|:||||
Mouse     4 FDPAELPELLKLYYRRLFPYAQYYRWLNYGGVTKNYFQHREFSFTLKDDIYIRYQSFNNQSELEK 68

  Fly    88 EICSRNPIKIDIGPVMHSKPKNHRSIP-GGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLKCWK 151
            |:...||.|||||.|...:|..|.::. |.....::||||||||||||:||.|||.|.:|.|||.
Mouse    69 EMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICSKCWT 133

  Fly   152 FMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYASFA 216
            .|.:|.|::|.||:|||||:|.:|::|||||:||||||...|.|....|..:.|||:::     .
Mouse   134 LMTMAMRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLV-----K 193

  Fly   217 GGN--SPRCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMV----HDDAARG 275
            ||.  ..:..:.::.|..:::::.|::..|||..|..|::....:...|:|.:|    ||:..||
Mouse   194 GGQDVKKKVHLNEKVHPFVRKSINIIKKYFEEYALVGQDILENKENWDKILALVPETIHDELQRG 258

  Fly   276 --ELESYMQKNLEDGAHSRLVWESFIKYANSMRTSTTSAWSRKLKN------IVAEIQLGLLYPR 332
              :..|..|:           ||...|.|||         |:.:||      :..|:.|...:||
Mouse   259 FQKFHSSPQR-----------WEHLRKVANS---------SQNMKNDKCGPWLEWEVMLQYCFPR 303

  Fly   333 LDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEIN--AFDDKSKSY 395
            ||:||::|.|||||:||.:||.||::.||.....|.:|||.|||||:.:..|::  :..:|.|..
Mouse   304 LDVNVSKGVNHLLKSPFSVHPKTGRISVPIDFHKVDQFDPFTVPTISAICRELDMVSTHEKEKEE 368

  Fly   396 MEAPEDKSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQ 437
            .|| :.|.|::.:||||:...|.|||:||..|::|:|...|:
Mouse   369 NEA-DSKHRVRGYKKTSLAPYVKVFEQFLENLDKSRKGELLK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha50	NP_523972.2	AE_Prim_S	41..372	CDD:240130	142/345 (41%)
Prim1	NP_032947.1	AE_Prim_S	26..343	CDD:240130	141/341 (41%)
Prim1	NP_032947.1	Zinc knuckle motif	121..131		5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837178
Domainoid	1	1.000	190	1.000	Domainoid score	I3272
eggNOG	1	0.900	-	-		E1_COG1467
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H730
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2347
Isobase	1	0.950	-	0	Normalized mean entropy	S1232
OMA	1	1.010	-	-		QHG54298
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004166
OrthoInspector	1	1.000	-	-		oto93522
orthoMCL	1	0.900	-	-		OOG6_101221
Panther	1	1.100	-	-	LDO	PTHR10536
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R980
SonicParanoid	1	1.000	-	-		X2917
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740