DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha50 and T24C4.5

DIOPT Version :9

Sequence 1:	NP_523972.2	Gene:	DNApol-alpha50 / 38942	FlyBaseID:	FBgn0011762	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001379895.1	Gene:	T24C4.5 / 188846	WormBaseID:	WBGene00020761	Length:	318	Species:	Caenorhabditis elegans

Alignment Length:	237	Identity:	98/237 - (41%)
Similarity:	140/237 - (59%)	Gaps:	16/237 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AYNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAELE 86
            :||...|...||:||:..||..||.:||.||.:....|:.||.:|.|.||::|||..::.:....
Worm     2 SYNSIRLPQDLPIYYKNFFPVKPFTKWLCYGQNYGDYFNRREFTFILADDVHIRYRSYNDEHSFV 66

  Fly    87 KEICSRNPIKIDIGPVMHSKPKNHRSIPGGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLKCWK 151
            |.:.|.||.|:|||.|.:.:|.|::... ....|:||||||||:||||.||.||..|.||.||||
Worm    67 KALSSTNPEKLDIGAVYNHEPINNKRYT-DYQAVERELVFDIDLTDYDPVRNCCKDATVCPKCWK 130

  Fly   152 FMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYASFA 216
            |||||.|:||..|.|.|.|:..:|:||||||:||||.|.:||.|:...|.|:|..||:..
Worm   131 FMVLAVRILDFQLEEMFNFKARMWVFSGRRGVHCWVGDKKARMLNNNQRSAIATRLNLFK----- 190

  Fly   217 GGNSPRCSMGD------RPHHSLKRALKIV--EPMFEEIVLE 250
              .:.:|.:.:      |...:::.|..:.  :.:||:::.|
Worm   191 --KNGQCEVTEGRAKLTRVPPTVRDAFNVALKDGVFEKMIYE 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha50	NP_523972.2	AE_Prim_S	41..372	CDD:240130	90/218 (41%)
T24C4.5	NP_001379895.1	AE_Prim_S	21..215	CDD:240130	86/201 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159381
Domainoid	1	1.000	155	1.000	Domainoid score	I2583
eggNOG	1	0.900	-	-		E1_COG1467
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H730
Inparanoid	1	1.050	245	1.000	Inparanoid score	I2049
Isobase	1	0.950	-	0	Normalized mean entropy	S1232
OMA	1	1.010	-	-		QHG54298
OrthoDB	1	1.010	-	-		D1346165at2759
OrthoFinder	1	1.000	-	-		FOG0004166
OrthoInspector	1	1.000	-	-		otm14410
orthoMCL	1	0.900	-	-		OOG6_101221
Panther	1	1.100	-	-	O	PTHR10536
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R980
SonicParanoid	1	1.000	-	-		X2917
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750