DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf6 and cpsf7

DIOPT Version :9

Sequence 1:	NP_648206.1	Gene:	Cpsf6 / 38937	FlyBaseID:	FBgn0035872	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_012816749.1	Gene:	cpsf7 / 779717	XenbaseID:	XB-GENE-5754390	Length:	462	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	197/597 - (32%)
Similarity:	278/597 - (46%)	Gaps:	154/597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAD--VVLDLYAEDLDKDF--AGQA-------QDEFGGDGVDLYDDIGGPTESAASGGGGGGTPS 54
            |||  .::|:|||:   :|  .|:.       :.||..:.||||||:......::|........|
Frog     1 MADGADLIDIYAEE---EFIQVGETRSGPKRNESEFAAEQVDLYDDVLAVPAISSSHVESNRNSS 62

  Fly    55 ADGAAGPGSGEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVS 119
            |.....|........|:..|..:||  ||      ..|..:|:||.:||||||.:...:|.:|:.
Frog    63 ALEPTSPVQSTSPMSNNKTPEVLYH--SG------RNRVSMYIGNFSWWTTDQQLLALIRSVGIK 119

  Fly   120 DLQEVKFFENRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQK 184
            |..|:||.|||||||||||:.:.|.||||:..:|:.||:|:::|:...|...::|.|:.||:|
Frog   120 DHVEIKFAENRANGQSKGFAEVILSSESSMNLILEHLPQKKLNGKKLDVRPANRQNLSFFEAL-- 182

  Fly   185 TRPVPPPQQNGPPRGPAPPSMGGGPMPTGHPGGPQGGGPPGHPPRGMNSIMQPGQYRPQHMSQVP 249
            :|...||:.|........            .|.|..|              :|....||
Frog   183 SRKKIPPRANSKSSSDLT------------DGSPTSG--------------EPTMVSPQ------ 215

  Fly   250 QVGGPNSGPPRMQPPMHPQGGLMGN---QQPPPRYPSAQGQWPGQRPGGPRPGPPNGPPQRPMFQ 311
                 ...|.|:.|       |:.|   .:.|.|.|....|         ||.....|||.|
Frog   216 -----AEAPKRIMP-------LLSNTCYAEAPSRIPVMTLQ---------RPTMTLPPPQSP--- 256

  Fly   312 GGPMGMPVRGPAGPDWRRPPMHGG--FPPQGPPRGLPP---APGPGGPHGAPAPHVNPAFFNQPG 371
                |:|......|   .||:|..  .||  |||.|||   .|.|||.  .||.|:|||||
Frog   257 ----GLPAAYRPPP---IPPLHYTHLMPP--PPRLLPPPLGMPPPGGV--PPALHLNPAFF---- 306

  Fly   372 GPAQHPGMGGPPHGAPGPQPGMNMPPQQGMNMTPQHGPPPQFAQHGPRGPWPPPQGKPPGPFPDP 436
                     .||:...||      ||:....:     |.|......|:||:||
Frog   307 ---------PPPNSVLGP------PPEPFKVI-----PNPYIHGRDPKGPFPP------------ 339

  Fly   437 QQMGPQLTEVEFEEVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCK 501
                  ::|.||||:|:|||.:|.||::.||..|.:|:|::||:||.|||::||:|:||:|:||:
Frog   340 ------VSEAEFEELMNRNRAISRSALSNAVCGATSGDYANAIKTLETAIAVIKESRVANDDRCR 398

  Fly   502 ILISSLQDTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGS 566
            :|::||:|.||||:.|:.:.|:|.||          |:||.||.||.|..|.||   ..:|....
Frog   399 VLLTSLKDCLHGIQDKANSSRKRHRS----------RDRSPSRSREGSSRRHRD---SHDRSDEY 450

  Fly   567 YRERSRSRERER 578
            |:||.|.::|.|
Frog   451 YQERHRDKDRHR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf6	NP_648206.1	RRM_CFIm68	94..170	CDD:241087	37/75 (49%)
cpsf7	XP_012816749.1	RRM_CFIm59	92..181	CDD:241088	41/88 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48498
OrthoDB	1	1.010	-	-		D1016696at2759
OrthoFinder	1	1.000	-	-		FOG0003643
OrthoInspector	1	1.000	-	-		otm48673
Panther	1	1.100	-	-	O	PTHR23204
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030