DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf6 and Cpsf7

DIOPT Version :9

Sequence 1:	NP_648206.1	Gene:	Cpsf6 / 38937	FlyBaseID:	FBgn0035872	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006231124.1	Gene:	Cpsf7 / 365407	RGDID:	1305441	Length:	471	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	214/598 - (35%)
Similarity:	287/598 - (47%)	Gaps:	152/598 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLDLYAEDLDKDFAGQAQDEFGG-DGVDLYDDIGGPTESAASGGGGGGTPSADGAAG-----PGS 63
            ::|:||   |::|  ....||.. |.:|||||:    .:|||      .||.|.::.     |..
  Rat     7 LIDIYA---DEEF--NQDSEFNNTDQIDLYDDV----LTAAS------QPSDDRSSSTEPPPPVR 56

  Fly    64 GEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVSDLQEVKFFE 128
            .||..:.:.....:.:..||    ..:||..:|||:.:||||||.:...:|.|||.|:.|:||.|
  Rat    57 QEPAPKPNNKTPAILYTYSG----LRSRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAE 117

  Fly   129 NRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQKTRP-VPPPQ 192
            |||||||||::.:.:.||:|:..:|:.||.|.::|:...|...::|.|:|||:..:.|. |..|:
  Rat   118 NRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPR 182

  Fly   193 QNGPPRG---PAPPSMGGGPMPTGH--PGGPQGGGPPGHPPRGMNSIMQPGQYRPQHMSQVPQVG 252
            ...|||.   .:..|..|...|:.:  |...:...||                     |.:|...
  Rat   183 GGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPP---------------------SVLPYFN 226

  Fly   253 GPNSGPPRMQPPMHPQGGLMGNQQPPPRYPSAQGQWPGQRPGGPRPGPPNGPPQRPMFQGGPMGM 317
            .|.|..|           |||  .|||..|                 ||  ||....|     |:
  Rat   227 RPPSALP-----------LMG--LPPPPIP-----------------PP--PPLSSSF-----GV 254

  Fly   318 PVRGPAGPDWRR--PPMHGGFPPQGPPRGLPPAPG--PGGPHGAPAPHVNPAFFNQPGGPAQHPG 378
            | ..|.|..::.  ||     ||:.||....|.||  |      ||.|:|||||
  Rat   255 P-PPPPGIHYQHLMPP-----PPRLPPHLAVPPPGAIP------PALHLNPAFF----------- 296

  Fly   379 MGGPPHGAPGPQPGMNMPPQQGMNMTPQHGPPPQFAQHGPRGPWPPPQGKPPGPFPDPQQMGPQL 443
              .||:...||.|...|...     ||       :..||.|         ..||.|.      .:
  Rat   297 --PPPNATVGPPPDTYMKAS-----TP-------YNHHGSR---------DSGPLPS------TV 332

  Fly   444 TEVEFEEVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCKILISSLQ 508
            :|.||||:|.|||.:|||||::|||.|:||:||.|||||:|||::||||:||:||||::|||||:
  Rat   333 SEAEFEEIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLK 397

  Fly   509 DTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGSYRERSRS 573
            |.|||||||||:......|..:.|||   ||||.||.||.|| |.||.....:|....::||:|.
  Rat   398 DCLHGIEAKSYSVGASGSSSRKRHRS---RERSPSRSRESSR-RHRDLLHNEDRHDDYFQERNRE 458

  Fly   574 RERERQAPDHYRD 586
            .||.|   |..||
  Rat   459 HERHR---DRERD 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf6	NP_648206.1	RRM_CFIm68	94..170	CDD:241087	36/75 (48%)
Cpsf7	XP_006231124.1	RRM	20..231	CDD:223796	77/245 (31%)
Cpsf7	XP_006231124.1	RRM_CFIm59	81..170	CDD:410049	41/88 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48498
OrthoDB	1	1.010	-	-		D1016696at2759
OrthoFinder	1	1.000	-	-		FOG0003643
OrthoInspector	1	1.000	-	-		otm45582
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23204
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820