DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf6 and cpsf6

DIOPT Version :9

Sequence 1:	NP_648206.1	Gene:	Cpsf6 / 38937	FlyBaseID:	FBgn0035872	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_005164508.1	Gene:	cpsf6 / 327069	ZFINID:	ZDB-GENE-030131-5277	Length:	571	Species:	Danio rerio

Alignment Length:	723	Identity:	286/723 - (39%)
Similarity:	353/723 - (48%)	Gaps:	224/723 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVV--LDLYAEDLDKDFAGQAQDEFGGDGVDLYDDIGGPTESAASGGGGGGTPSADGAAGPGS 63
            |||.|  :|:|| |::::| .|..|....|.:|||||:..|  ||.:|.........|....||.
Zfish     1 MADGVDHIDIYA-DVEEEF-NQESDYPVHDQIDLYDDVISP--SANNGDAPEDRDYLDSLPAPGG 61

  Fly    64 GEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVSDLQEVKFFE 128
               .|.:.|.|..|.:..:|       :|..||:|||||||||:|:.:::|.||::|:.|:||||
Zfish    62 ---NEGSKGAPANVVYTYNG-------KRIALYIGNLTWWTTDEDLTDAIRSIGINDVLEIKFFE 116

  Fly   129 NRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQKT-------- 185
            ||||||||||:::.:||:||.|.::|.|.|:|:|||.|:||..:||:|:|||...:.
Zfish   117 NRANGQSKGFALVCVGSDSSSRKLMDLLSKRELHGQNPIVTPCNKQSLSQFEMQSRKSERRGFDN 181

  Fly   186 ----------------RPVPP---------PQQNGPPRGPAPPSMG---------GGPMPTGH-- 214
                            :..||         |...|..|.|.||..|         |||.|  |
Zfish   182 SHYHKGTQSGQMSGEGKAGPPGSGSRGGGFPPGKGQRRFPGPPGQGDRFPGPVGPGGPPP--HFP 244

  Fly   215 --------PGGPQGG-GPPGHPPRGMNSIMQPGQYRPQHMSQVPQVGGPNSGPPRMQPPMHPQGG 270
                    |.||.|. ||||.||        |||..|      |.:|||   |.|
Zfish   245 GMQGPPRLPSGPPGPLGPPGPPP--------PGQGLP------PPLGGP---PNR---------- 282

  Fly   271 LMGNQQPPP-RYPSAQGQWP-GQRPGGPRP---GPPNGPPQRPMFQGGPMGMPVRGPAGPDWRRP 330
              |::.||| .:|...||.| |..|.||.|   |||.|||  |..||.|       |.||...||
Zfish   283 --GDRPPPPVLFPGQFGQPPMGPMPPGPPPPGYGPPPGPP--PPQQGPP-------PPGPFPPRP 336

  Fly   331 PMHGGFPPQGPPRGLPP-----APGPGGPHGAPAPHVNPAFFNQPGGPAQHPGMGGPPHGAPGPQ 390
            |     .|.|||.||.|     .|.||||  .||||||||||                     |.
Zfish   337 P-----GPLGPPLGLAPPPHMQGPPPGGP--PPAPHVNPAFF---------------------PP 373

  Fly   391 PGMNMPPQQGMNMTPQHGPPPQFAQHGPRGPWPPPQGKPP---GPFPDPQQMGPQ---LTEVEFE 449
            ||.|||...|      .||||           ..|.|:||   ..||..:.|...   |:|.|||
Zfish   374 PGNNMPSSDG------RGPPP-----------GDPYGRPPPYDRDFPGGRDMDASRTPLSEAEFE 421

  Fly   450 EVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCKILISSLQDTLHGI 514
            |:|:|||.:|||||:||||||:|.:|.||||||||||||||||||:.|:|||:|||||||.||||
Zfish   422 EIMNRNRAISSSAISRAVSDASAADYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGI 486

  Fly   515 EAKSYNRRERSRS-RERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGSYRERSRSRERER 578
            |:|||.....:.: ..:.|....|||||          ||||..|.||:   |.|.:||||:|..
Zfish   487 ESKSYGSVAGAMADLNQGHNGFYRRERS----------RERDHSRSREK---SRRHKSRSRDRHE 538

  Fly   579 QAPDHYRDDSRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRERRDRDRDRDRERERDRD 643
               |:||:.||                                     .|||.|:|||:|||||:
Zfish   539 ---DYYRERSR-------------------------------------ERDRHRERDRDRERDRE 563

  Fly   644 RREEHRSR 651
            |..|:|.|
Zfish   564 REREYRHR 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf6	NP_648206.1	RRM_CFIm68	94..170	CDD:241087	45/75 (60%)
cpsf6	XP_005164508.1	RRM_CFIm68	82..158	CDD:241087	45/75 (60%)
cpsf6	XP_005164508.1	RSB_motif	505..>539	CDD:292910	20/49 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576371
Domainoid	1	1.000	266	1.000	Domainoid score	I1849
eggNOG	1	0.900	-	-		E1_KOG4849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1941
OMA	1	1.010	-	-		QHG48498
OrthoDB	1	1.010	-	-		D1016696at2759
OrthoFinder	1	1.000	-	-		FOG0003643
OrthoInspector	1	1.000	-	-		oto41581
orthoMCL	1	0.900	-	-		OOG6_108776
Panther	1	1.100	-	-	LDO	PTHR23204
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860