Protein Alignment Cpsf6 and Cpsf7

DIOPT Version :10

• Sequence 1: NP_648206.1
• Gene: Cpsf6 / 38937
• FlyBaseID: FBgn0035872
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_758506.3
• Gene: Cpsf7 / 269061
• MGIID: 1917826
• Length: 471
• Species: Mus musculus
• Alignment Length: 598
• Identity: 214/598 - (35%)
• Similarity: 287/598 - (47%)
• Gaps: 152/598 - (25%)

  Fly     5 VLDLYAEDLDKDFAGQAQDEFGG-DGVDLYDDIGGPTESAASGGGGGGTPSADGAAG-----PGS 63
            ::|:||   |::|  ....||.. |.:|||||:    .:|||      .||.|.::.     |..
Mouse     7 LIDIYA---DEEF--NQDSEFNNTDQIDLYDDV----LTAAS------QPSDDRSSSTEPPPPVR 56

  Fly    64 GEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVSDLQEVKFFE 128
            .||..:.:.....:.:..||    ..:||..:|||:.:||||||.:...:|.|||.|:.|:||.|
Mouse    57 QEPAPKPNNKTPAILYTYSG----LRSRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAE 117

  Fly   129 NRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQKTRP-VPPPQ 192
            |||||||||::.:.:.||:|:..:|:.||.|.::|:...|...::|.|:|||:..:.|. |..|:
Mouse   118 NRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPR 182

  Fly   193 QNGPPRG---PAPPSMGGGPMPTGH--PGGPQGGGPPGHPPRGMNSIMQPGQYRPQHMSQVPQVG 252
            ...|||.   .:..|..|...|:.:  |...:...||                     |.:|...
Mouse   183 GGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPP---------------------SVLPYFN 226

  Fly   253 GPNSGPPRMQPPMHPQGGLMGNQQPPPRYPSAQGQWPGQRPGGPRPGPPNGPPQRPMFQGGPMGM 317
            .|.|..|           |||  .|||..|                 ||  ||....|     |:
Mouse   227 RPPSALP-----------LMG--LPPPPIP-----------------PP--PPLSSSF-----GV 254

  Fly   318 PVRGPAGPDWRR--PPMHGGFPPQGPPRGLPPAPG--PGGPHGAPAPHVNPAFFNQPGGPAQHPG 378
            | ..|.|..::.  ||     ||:.||....|.||  |      ||.|:|||||
Mouse   255 P-PPPPGIHYQHLMPP-----PPRLPPHLAVPPPGAIP------PALHLNPAFF----------- 296

  Fly   379 MGGPPHGAPGPQPGMNMPPQQGMNMTPQHGPPPQFAQHGPRGPWPPPQGKPPGPFPDPQQMGPQL 443
              .||:...||.|...|...     ||       :..||.|...|||.               .:
Mouse   297 --PPPNATVGPPPDTYMKAS-----TP-------YNHHGSRDSGPPPS---------------TV 332

  Fly   444 TEVEFEEVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCKILISSLQ 508
            :|.||||:|.|||.:|||||::|||.|:||:||.|||||:|||::||||:||:||||::|||||:
Mouse   333 SEAEFEEIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLK 397

  Fly   509 DTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGSYRERSRS 573
            |.|||||||||:......|..:.|||   ||||.||.||.|| |.||.....:|....::||:|.
Mouse   398 DCLHGIEAKSYSVGASGSSSRKRHRS---RERSPSRSRESSR-RHRDLLHNEDRHDDYFQERNRE 458

  Fly   574 RERERQAPDHYRD 586
            .||.|   |..||
Mouse   459 HERHR---DRERD 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf6	NP_648206.1	RRM_CFIm68	94..170	CDD:410048	36/75 (48%)
		PABP-1234	<131..287	CDD:130689	45/161 (28%)
		Med15	159..>439	CDD:312941	73/289 (25%)
Cpsf7	NP_758506.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..68		9/43 (21%)
		RRM_CFIm59	81..170	CDD:410049	41/88 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..220		11/64 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..471		27/67 (40%)
		Arg/Ser-rich domain. /evidence=ECO:0000250|UniProtKB:Q8N684	418..469		26/58 (45%)