Protein Alignment Rab19 and RAB1B

DIOPT Version :10

• Sequence 1: NP_523970.1
• Gene: Rab19 / 38930
• FlyBaseID: FBgn0015793
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_112243.1
• Gene: RAB1B / 81876
• HGNCID: 18370
• Length: 201
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 96/216 - (44%)
• Similarity: 137/216 - (63%)
• Gaps: 21/216 - (9%)

  Fly     5 NPQTLMALPNEEHFDFLFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAVEGKQ 69
            ||:          :|:|||::||||.|.||:|::.||....|.|.:.:||||||.::||.::||.
Human     2 NPE----------YDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT 56

  Fly    70 IKLQIWDTAGQERFRTITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTASNVLIILVGN 134
            ||||||||||||||||||.||||.|:|:::|||:|.:.|::|:::|::|:.||.:.||..:||||
Human    57 IKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGN 121

  Fly   135 KCDLEEQREVDFEEARQMCQY--IPEILFVMETSAKENMNVEDAFRCLANELKRQ--HDANNVEE 195
            |.||..::.||...|::....  ||    .:|||||...|||.||..:|.|:|::  ..|.:..|
Human   122 KSDLTTKKVVDNTTAKEFADSLGIP----FLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGE 182

  Fly   196 VPENTITLGQGKPLKSCSSSC 216
            .|...|   ...|:|.....|
Human   183 RPNLKI---DSTPVKPAGGGC 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab19	NP_523970.1	Rab19	19..184	CDD:133267	85/166 (51%)
RAB1B	NP_112243.1	Rab1_Ypt1	7..172	CDD:206661	86/168 (51%)
		Switch 1. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	30..45		6/14 (43%)
		Switch 2 region, required for interaction with REP1/CHM	64..83		16/18 (89%)
		Switch 2. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	65..80		13/14 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		7/30 (23%)