Protein Alignment Rab19 and RAB7A

DIOPT Version :10

• Sequence 1: NP_523970.1
• Gene: Rab19 / 38930
• FlyBaseID: FBgn0015793
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Alignment Length: 202
• Identity: 71/202 - (35%)
• Similarity: 119/202 - (58%)
• Gaps: 8/202 - (3%)

  Fly    21 LFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAVEGKQIKLQIWDTAGQERFRT 85
            |.|::::||.|.|||.:::::....:..::..|||.||..|.:.|:.:.:.:|||||||||||::
Human     8 LLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQS 72

  Fly    86 ITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTA----SNVLIILVGNKCDLEEQREVDF 146
            :..::||.|:..::|:|:|..::|..|..|.:|.....:    .|...:::|||.|| |.|:|..
Human    73 LGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDL-ENRQVAT 136

  Fly   147 EEARQMCQYIPEILFVMETSAKENMNVEDAFRCLA-NELKRQHDANNVEEVPENTITLGQGKPLK 210
            :.|:..| |....:...||||||.:|||.||:.:| |.||::.:.....|.|| .|.|.:....|
Human   137 KRAQAWC-YSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPE-PIKLDKNDRAK 199

  Fly   211 SCSSSCN 217
            :.:.||:
Human   200 ASAESCS 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab19	NP_523970.1	Rab19	19..184	CDD:133267	61/167 (37%)
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	62/171 (36%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		0/12 (0%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		6/14 (43%)