Protein Alignment Rab19 and RAB5A

DIOPT Version :10

• Sequence 1: NP_523970.1
• Gene: Rab19 / 38930
• FlyBaseID: FBgn0015793
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 76/208 - (36%)
• Similarity: 116/208 - (55%)
• Gaps: 11/208 - (5%)

  Fly    13 PNEEHFDFLFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAVEGKQIKLQIWDT 77
            ||..:....||:||:|:...||:.:|.||..|.:.|...:|||..|..:|:.::...:|.:||||
Human    12 PNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDT 76

  Fly    78 AGQERFRTITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTASNVLIILVGNKCDLEEQR 142
            |||||:.::...|||.|...::|||||...||:..:.|::|::|..:.|::|.|.|||.||..:|
Human    77 AGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKR 141

  Fly   143 EVDFEEARQMCQYIPEILFVMETSAKENMNVEDAFRCLANELKRQHDANNVEEVPENTITLGQG- 206
            .|||:||:....  ...|..||||||.:|||.:.|..:|.:|.:....|     |......|:|
Human   142 AVDFQEAQSYAD--DNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQN-----PGANSARGRGV 199

  Fly   207 ---KPLKSCSSSC 216
               :|.:...:.|
Human   200 DLTEPTQPTRNQC 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab19	NP_523970.1	Rab19	19..184	CDD:133267	67/164 (41%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	67/163 (41%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		4/11 (36%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		8/15 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		7/37 (19%)