Protein Alignment Rab19 and RAB3B

DIOPT Version :10

• Sequence 1: NP_523970.1
• Gene: Rab19 / 38930
• FlyBaseID: FBgn0015793
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_002858.2
• Gene: RAB3B / 5865
• HGNCID: 9778
• Length: 219
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 80/208 - (38%)
• Similarity: 129/208 - (62%)
• Gaps: 8/208 - (3%)

  Fly    14 NEEHFDFLFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAVEGKQIKLQIWDTA 78
            ::::||::||:::||:...|||..:.|:....:.....:|:|:||.:||:....|::||||||||
Human    15 SDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTA 79

  Fly    79 GQERFRTITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTASNVLIILVGNKCDLEEQRE 143
            ||||:||||.:|||.|.|.:::||||...||:.:|.|..:::.|:..|..:||||||||:||:|.
Human    80 GQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERV 144

  Fly   144 VDFEEARQMCQYIPEILFVMETSAKENMNVEDAFRCLANEL-KRQHDANNVEE----VPENTITL 203
            |..|:.:.:.:.:....|  |.|||||::|..||..|.:.: .:..|:.:.:.    ..:|| .|
Human   145 VPTEKGQLLAEQLGFDFF--EASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNT-RL 206

  Fly   204 GQGKPLKSCSSSC 216
            ....||...:.||
Human   207 SDTPPLLQQNCSC 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab19	NP_523970.1	Rab19	19..184	CDD:133267	71/164 (43%)
RAB3B	NP_002858.2	Rab3	22..186	CDD:206657	70/165 (42%)
		Switch 1. /evidence=ECO:0000269|PubMed:35871249, ECO:0007744|PDB:8A4B	45..58		2/12 (17%)
		Switch 2. /evidence=ECO:0000269|PubMed:35871249, ECO:0007744|PDB:8A4B	78..96		13/17 (76%)