Protein Alignment Rab19 and RAB1A

DIOPT Version :10

• Sequence 1: NP_523970.1
• Gene: Rab19 / 38930
• FlyBaseID: FBgn0015793
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_004152.1
• Gene: RAB1A / 5861
• HGNCID: 9758
• Length: 205
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 96/218 - (44%)
• Similarity: 140/218 - (64%)
• Gaps: 16/218 - (7%)

  Fly     1 MTARNPQTLMALPNEEHFDFLFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAV 65
            |::.||:          :|:|||::||||.|.||:|::.||....|.|.:.:||||||.::||.:
Human     1 MSSMNPE----------YDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIEL 55

  Fly    66 EGKQIKLQIWDTAGQERFRTITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTASNVLII 130
            :||.||||||||||||||||||.||||.|:|:::|||:|.:.||:|:::|::|:.||.:.||..:
Human    56 DGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKL 120

  Fly   131 LVGNKCDLEEQREVDFEEARQMCQY--IPEILFVMETSAKENMNVEDAFRCLANELKRQHDANNV 193
            ||||||||..::.||:..|::....  ||    .:|||||...|||.:|..:|.|:|::......
Human   121 LVGNKCDLTTKKVVDYTTAKEFADSLGIP----FLETSAKNATNVEQSFMTMAAEIKKRMGPGAT 181

  Fly   194 EEVPENTITLGQGKPLKSCSSSC 216
            ....|.:....|..|:|.....|
Human   182 AGGAEKSNVKIQSTPVKQSGGGC 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab19	NP_523970.1	Rab19	19..184	CDD:133267	86/166 (52%)
RAB1A	NP_004152.1	Rab1_Ypt1	10..175	CDD:206661	87/168 (52%)
		Switch 1. /evidence=ECO:0000269|PubMed:22416225, ECO:0007744|PDB:3SFV, ECO:0007744|PDB:3TKL	34..48		6/13 (46%)
		Switch 2. /evidence=ECO:0000269|PubMed:22416225, ECO:0007744|PDB:3SFV, ECO:0007744|PDB:3TKL	66..83		15/16 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..205		5/27 (19%)