Protein Alignment cert and PLEKHA8

DIOPT Version :9

• Sequence 1: NP_001286978.1
• Gene: cert / 38928
• FlyBaseID: FBgn0027569
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001183955.1
• Gene: PLEKHA8 / 84725
• HGNCID: 30037
• Length: 519
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 130/601 - (21%)
• Similarity: 213/601 - (35%)
• Gaps: 218/601 - (36%)

  Fly    42 LRGYLSKWTNYIYGWQPRYIVLKDGTLSYYKSESESDFGCRGAISLTKATIKAHESDELRFDVVV 106
            :.|.|.|||||:.|||||:.:|..|.||||.|..::..||:|:|.:....|:.|..|..|.|:::
Human     1 MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLII 65

  Fly   107 NNLNNWCLRAETSEDRMHWVDVLQLYKADSGSTDTTSLRRHGSTMSLQSNTISLTSGGSLKKTQR 171
            .....:.|:|.:..:|..|  ::.|..|.:..||:    |.........||             .
Human    66 PGEQYFYLKARSVAERQRW--LVALGSAKACLTDS----RTQKEKEFAENT-------------E 111

  Fly   172 NLREKVGELETFKDILFGQIETLQRYFDACSEVN----KNNAQPLDLGDGLKSIDFKGESITFRA 232
            ||:.|:.||..:.|:|..|:       |...||.    .|:.:.:|:|..|||
Human   112 NLKTKMSELRLYCDLLVQQV-------DKTKEVTTTGVSNSEEGIDVGTLLKS------------ 157

  Fly   233 TTSGVLTTLQHCLEI-------------------------------IAESDESWKRKLE------ 260
            |.:..|.||:.|::|                               |.....|.:|::|
Human   158 TCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCEN 222

  Fly   261 -------------------------REIDKRRRSEDQSK---------KLKDEVEKMK----RLS 287
                                     .|||....||:.:.         :.:|.:|.:|    .|:
Human   223 GSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLT 287

  Fly   288 YPGPD--------FEEGPHSTLPEDEFFDAVETGLDKIE--EDMQLRFKLKLQSQISQTLVNVPH 342
            ..|.|        :||| ...:|  .||..:.|....||  ||.                 .:|.
Human   288 QSGSDSSCSPECLWEEG-KEVIP--TFFSTMNTSFSDIELLEDS-----------------GIPT 332

  Fly   343 EAVAEGEEAREEFGTGAEATSHALWPEIDRVCKEQLHYAREGVGQDGNGWQIFADEGEIKMYKRE 407
            ||..              |:.:|:.|.:|::                 |..:||   .:||
Human   333 EAFL--------------ASCYAVVPVLDKL-----------------GPTVFA---PVKM---- 359

  Fly   408 EEVNGLVMDPLKAYHTVQGVTAREMCHYFFMPEFRNDWETTLEDCTILEKISADTLLFLQ--THK 470
             ::.|.:....:.|     :|.:|        ||     |||:. .:|.::.||......  |..
Human   360 -DLVGNIKKVNQKY-----ITNKE--------EF-----TTLQK-IVLHEVEADVAQVRNSATEA 404

  Fly   471 RIWPASQRDAQFWSHMRKITDNLEPGARDMWVVCNNSTEYAKQ-ESKNGKCVR-IFLTVILACQT 533
            .:|  .:|..:|   ::.....::.|.:|:....||:  |.|. ...:|..|| :|...:.|..:
Human   405 LLW--LKRGLKF---LKGFLTEVKNGEKDIQTALNNA--YGKTLRQHHGWVVRGVFALALRAAPS 462

  Fly   534 HLPEGYVKGQPLNRND 549
            :  |.:|....:...|
Human   463 Y--EDFVAALTVKEGD 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594	32/87 (37%)
		PH_GPBP	42..142	CDD:270100	36/99 (36%)
		START_STARD11-like	363..601	CDD:176881	38/191 (20%)
PLEKHA8	NP_001183955.1	PH_FAPP1_FAPP2	1..100	CDD:269951	36/104 (35%)
		Glycolipid transfer protein homology domain	310..519		49/251 (20%)
		GLTP	333..470	CDD:312299	40/203 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910