DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cert and Plekha3

DIOPT Version :9

Sequence 1:	NP_001286978.1	Gene:	cert / 38928	FlyBaseID:	FBgn0027569	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_112546.1	Gene:	Plekha3 / 83435	MGIID:	1932515	Length:	297	Species:	Mus musculus

Alignment Length:	265	Identity:	71/265 - (26%)
Similarity:	122/265 - (46%)	Gaps:	41/265 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LRGYLSKWTNYIYGWQPRYIVLKDGTLSYYKSESESDFGCRGAISLTKATIKAHESDELRFDVVV 106
            :.|.|.|||||:.|||||:.||.:|.||||.|:.:...|.:|:|.:....||.|.:|..|.::::
Mouse     1 MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHPADNTRMELII 65

  Fly   107 NNLNNWCLRAETSEDRMHWVDVLQLYKADSGSTDTTSLRRHGSTMSLQSNTISLTSGGSLKKTQR 171
            ....::.::|..:.:|..|:..|...||  ..|||.:.:..                 .:.:|..
Mouse    66 PGEQHFYMKAVNAAERQRWLVALGSSKA--CLTDTRTAKEK-----------------EISETSE 111

  Fly   172 NLREKVGELETFKDILFGQIETLQRYFDACSEVNKNNAQPLDLGDGLKSIDFKGE-SITFRATTS 235
            :|:.|:.||..:.|:|..|:.|:|.:      |:::...|      ..|::...| |....||.:
Mouse   112 SLKTKMSELRLYCDLLMQQVHTIQEF------VHRDERHP------SPSVENMNEASSLLSATCN 164

  Fly   236 GVLTTLQHCLEIIAESDESWKRKLEREIDKRRRSED-QSKKLKDEVEKMKR-LSYPGPDFEEGPH 298
            ..:|||:.|::|.       ..|.:.|:.:....:. .|......|:.||| .|:||....|...
Mouse   165 TFITTLEECVKIA-------NAKFKPEMFQLPHPDPLVSPVSPSPVQMMKRSASHPGSCSSERSS 222

  Fly   299 STLPE 303
            .::.|
Mouse   223 CSIKE 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594	31/87 (36%)
		PH_GPBP	42..142	CDD:270100	36/99 (36%)
		START_STARD11-like	363..601	CDD:176881
Plekha3	NP_112546.1	PH_FAPP1_FAPP2	1..100	CDD:269951	37/100 (37%)
		Interaction with SACM1L. /evidence=ECO:0000250\|UniProtKB:Q9HB20	1..100		37/100 (37%)
		Interaction with VAPA and VAPB. /evidence=ECO:0000250\|UniProtKB:Q9HB20	97..297		36/167 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..297		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910