DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cert and SBF2

DIOPT Version :9

Sequence 1:	NP_001286978.1	Gene:	cert / 38928	FlyBaseID:	FBgn0027569	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001373268.1	Gene:	SBF2 / 81846	HGNCID:	2135	Length:	1881	Species:	Homo sapiens

Alignment Length:	153	Identity:	44/153 - (28%)
Similarity:	70/153 - (45%)	Gaps:	29/153 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTNAGESLGASPPSSN---EAAAGSQSQ-SDASEEEEYLDNSIELRGYLSKWTNYIYGWQPRYIV 62
            |::.||...:|...||   ..||...|| :..::|....:.::..||.|.|      ||:||:.|
Human  1740 DSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLK------GWKPRWFV 1798

  Fly    63 LKDGT---LSYYKSESESDFGCRGAISLTKATI----------KAHESDELRFDVVVN-NLNNWC 113
            | |.|   |.||  :|..|..|:|.|.|.:..:          ..|.||:..||:..: .:.|:|
Human  1799 L-DVTKHQLRYY--DSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFC 1860

  Fly   114 LRAETSEDRMHWVDVLQLYKADS 136
              |:..:....|:|.:|...:|:
Human  1861 --AQDGQSAQQWMDKIQSCISDA 1881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594	31/103 (30%)
		PH_GPBP	42..142	CDD:270100	33/109 (30%)
		START_STARD11-like	363..601	CDD:176881
SBF2	NP_001373268.1	uDENN	1..86	CDD:214824
		DENN	116..298	CDD:396629
		dDENN	352..420	CDD:129037
		SBF2	531..754	CDD:403522
		PH-GRAM_MTMR13	882..1000	CDD:275416
		PTP-MTMR13	1138..1517	CDD:350437
		Required for homodimerization and interaction with MTMR2. /evidence=ECO:0000250\|UniProtKB:E9PXF8, ECO:0000269\|PubMed:15998640	1661..1714
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1706..1726
		PH_Sbf1_hMTMR5	1774..1879	CDD:269941	33/115 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910