DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cert and cert1b

DIOPT Version :9

Sequence 1:	NP_001286978.1	Gene:	cert / 38928	FlyBaseID:	FBgn0027569	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_021324631.1	Gene:	cert1b / 797430	ZFINID:	ZDB-GENE-110125-5	Length:	512	Species:	Danio rerio

Alignment Length:	527	Identity:	228/527 - (43%)
Similarity:	320/527 - (60%)	Gaps:	71/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LYKADSGSTDTTSLRRHGSTMSLQSNT--ISLTSGGSLKKTQRNLREKVGELETFKDILFGQIET 193
            :.||:||....:|||||||.:||.|.|  .|.||..|.|| ..:||||:.|:|||:|||..|::|
Zfish     1 MLKAESGYGSESSLRRHGSMLSLTSATSGYSATSTSSFKK-GHSLREKLAEMETFRDILCRQVDT 64

  Fly   194 LQRYFDACSE-VNKNNAQ------------PLDLGD---------------------GLKSIDFK 224
            ||:|||.|:: |||:..|            |....|                     |:..||||
Zfish    65 LQKYFDGCADAVNKDELQRDKIVEDDEDDFPTTRPDGEFLHNNNGSKEKLFQCLSHKGINGIDFK 129

  Fly   225 GESITFRATTSGVLTTLQHCLEIIAESDESWKRKLEREIDKRRRSEDQSKKLKDEVEKMKRLSYP 289
            ||:|||:|||:|:|.||.||::::.:.::||:::|::|::||||.|:..|....|::  |:..:.
Zfish   130 GEAITFKATTAGILATLSHCIDLMVKREDSWQKRLDKEMEKRRRVEEAYKSALSELK--KKSHFG 192

  Fly   290 GPDFEEGPHSTLPEDEFFDAVETGL---DKIEEDMQLRFKLKLQSQISQTLVNVPHEAV------ 345
            |||:||||:|.:.|||||||||..|   |||||..... |.::|...|     ||...|
Zfish   193 GPDYEEGPNSLINEDEFFDAVEAALDRQDKIEEQSHCE-KSRIQRSSS-----VPSGDVFSIVGS 251

  Fly   346 ---AEGEEAREEFGTGAEAT------SHALWPEIDRVCKEQLHYAREGVGQDGNGWQIFADEGEI 401
               ||...:|....:.:...      .|....|::.:.:..:.|:.:.||.|.| ||:..:|||:
Zfish   252 HRFAEKPPSRPPSPSSSAVVFTSSLHEHRFSAEVEEMVQNHMTYSLQDVGGDAN-WQLVVEEGEM 315

  Fly   402 KMYKREEEVNGLVMDPLKAYHTVQGVTAREMCHYFFMPEFRNDWETTLEDCTILEKISADTLLFL 466
            |:|:||.|.||:|:|||||.|.|:|||..|:|.||:..:.|||||||:|:..|:|.:|.:.::..
Zfish   316 KVYRREVEENGIVLDPLKATHCVKGVTGHEVCQYFWDTDVRNDWETTVENFNIVETLSDNAIIIY 380

  Fly   467 QTHKRIWPASQRDAQFWSHMRKITDNLEPGARDMWVVCNNSTEYAKQESKNGKCVRIFLTVILAC 531
            |||||:|||||||..:.|.:|||..|.| ...|.|:|||.|.|:...: .|.:|||..:.:.:.|
Zfish   381 QTHKRVWPASQRDVLYLSAIRKIMANNE-NDPDTWLVCNFSVEHDNAQ-PNNRCVRAKINIAMIC 443

  Fly   532 QTHL--PEGYVKGQPLNRNDLTCKITYCSVVNPGGWAPASALRAVYKREYPKFLKRFTGYVIDQC 594
            ||.:  |||   .:.::|:::||||||.:.||||||||||.||||.||||||||||||.||.::.
Zfish   444 QTLVSPPEG---DKEISRDNITCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKT 505

  Fly   595 KDKPIMF 601
            ..|||:|
Zfish   506 AGKPILF 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594
		PH_GPBP	42..142	CDD:270100	4/10 (40%)
		START_STARD11-like	363..601	CDD:176881	118/239 (49%)
cert1b	XP_021324631.1	START_STARD11-like	278..512	CDD:176881	118/239 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579593
Domainoid	1	1.000	220	1.000	Domainoid score	I2560
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4173
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1419
OMA	1	1.010	-	-		QHG52378
OrthoDB	1	1.010	-	-		D408116at33208
OrthoFinder	1	1.000	-	-		FOG0006557
OrthoInspector	1	1.000	-	-		otm25503
orthoMCL	1	0.900	-	-		OOG6_106305
Panther	1	1.100	-	-	LDO	PTHR10219
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910