DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cert and Osbp

DIOPT Version :9

Sequence 1:	NP_001286978.1	Gene:	cert / 38928	FlyBaseID:	FBgn0027569	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	125/551 - (22%)
Similarity:	207/551 - (37%)	Gaps:	110/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ELRGYLSKWTNYIYGWQPRYIVLKDGTLSYYKSESESDFGCRGAISLTKATIKAHESDELRFDVV 105
            |::|:|.||||||.|:|.|:.||..|.||||:::||.:..|||.|||..|.|  |..|...|.:.
  Fly    16 EMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALI--HTVDSCTFVIS 78

  Fly   106 VNNLNNWCLRAETSEDRMHWVDVLQLYKADSGSTDTTSLRRHGSTMSLQSNTISLTSGGSLKKTQ 170
            ......:.::|.|..:|..||..|:|.||       .::|........::.|..:.....:....
  Fly    79 NGGTQTFHIKAGTEVERQSWVTALELAKA-------KAIRAIECEEEEETETAHVVPSQEISSVV 136

  Fly   171 RNLREKVGELETFKDILFGQIETLQRYFDACSEVNKNNAQPLDLGDGLKSIDFKGESITFRATTS 235
            |:|.:::..:.|..|::......|||   |.:::..|..:  .||...|.::.:  :..||.|::
  Fly   137 RDLTDRLESMRTCYDLITKHGAALQR---ALNDLETNEEE--SLGSRTKIVNER--ATLFRITSN 194

  Fly   236 GVLTTLQHCLEIIAESDESWKRKLEREIDKRRRSE---DQSKKLKDEVEKM-------KRLSYPG 290
            .::......|.........|.:.|..|.::|:|.|   :|..|.:.::|:.       |.:|...
  Fly   195 AMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPVSSTS 259

  Fly   291 PDFEEGPHSTLPED-EFFDAVE---TGLDKIEEDMQLR---FKLKLQSQISQTLVNVPHEAVAEG 348
            .....|...|..|: |||||.|   :|..:..|.....   |.||:..:.|.:...|........
  Fly   260 GAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSS 324

  Fly   349 EEAREEFGTGAEATSHALWPEIDRVCKEQL-HYAREGVGQD------------------GNGWQI 394
            .|:.|:..|         ...:.:||.... ..|..|.|.|                  |..|
  Fly   325 SESDEQKRT---------VQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNW-- 378

  Fly   395 FADEGEIKMYKREEEVNGLVMDPLKAYHTVQGVTAREMCHYFFMPEFR----------NDWE--- 446
              :...||  ||.:.|......|:..:..::....:::........|.          .|:|
  Fly   379 --NPDLIK--KRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTE 439

  Fly   447 ------TTLEDCTILEKISADTL-LFLQTHKR-----------IWPASQRDAQFWSHMRKITDNL 493
                  |..::|..|..|:|.|: .:..|..|           .:...:.|...|..:.:...:.
  Fly   440 ILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHH 504

  Fly   494 EPGARDMWVVCNNSTEYAKQESKNGKCVRIF 524
            .|.|.   :.|         ||||..|.:.|
  Fly   505 PPVAA---LHC---------ESKNWTCWQEF 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594	37/88 (42%)
		PH_GPBP	42..142	CDD:270100	40/99 (40%)
		START_STARD11-like	363..601	CDD:176881	36/212 (17%)
Osbp	NP_477271.1	PH	15..107	CDD:278594	39/92 (42%)
		PH_OSBP_ORP4	17..113	CDD:270101	41/104 (39%)
		Oxysterol_BP	399..764	CDD:279564	22/137 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I3888
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910