DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cert and cert1

DIOPT Version :9

Sequence 1:	NP_001286978.1	Gene:	cert / 38928	FlyBaseID:	FBgn0027569	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_988844.1	Gene:	cert1 / 387331	XenbaseID:	XB-GENE-1002414	Length:	617	Species:	Xenopus tropicalis

Alignment Length:	647	Identity:	268/647 - (41%)
Similarity:	393/647 - (60%)	Gaps:	91/647 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSNEAAAGSQSQSDASEEEEYLDNSIELRGYLSKWTNYIYGWQPRYIVLKDGTLSYYKSESESDF 79
            |.|::...|.|:.|...|.   ...:|..|.||||||||:|||.|::|||:.||||||||.|:::
Frog     2 SDNQSWNSSGSEEDLETES---GPPVERCGVLSKWTNYIHGWQDRWVVLKNNTLSYYKSEDETEY 63

  Fly    80 GCRGAISLTKATIKAHESDELRFDVVVNNLNNWCLRAETSEDRMHWVDVLQLYKADSGSTDTTSL 144
            ||||:|.|:||.|..||.||.|||:.||: :.|.|||:..:.|..|:|.::.:|::||....:||
Frog    64 GCRGSICLSKAVITPHEFDECRFDISVND-SVWYLRAQDPDHRQRWIDSIEQHKSESGYGSESSL 127

  Fly   145 RRHGSTMSLQSNT--ISLTSGGSLKKTQRNLREKVGELETFKDILFGQIETLQRYFDACSE-VNK 206
            |||||.:||.|..  .|.||..|.|| ..:||||:.|:|||:|||..|::|||:|||||:: |:|
Frog   128 RRHGSMVSLVSGASGYSATSTSSFKK-GHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSK 191

  Fly   207 NNAQPLDLGD--------------------------------GLKSIDFKGESITFRATTSGVLT 239
            :..:...:.|                                |:..||||||:|||:|||:|:|.
Frog   192 DELERDKVEDDEDDFLHSHPNGDYIHSSIGSKDKLFQHVSPKGINGIDFKGEAITFKATTAGILA 256

  Fly   240 TLQHCLEIIAESDESWKRKLEREIDKRRRSEDQSKKLKDEVEKMKRLSYPGPDFEEGPHSTLPED 304
            ||.||::::.:.::||:::|::||:||||.|:..|....|::  |:..:.|||:||||:|.:.|:
Frog   257 TLSHCIDLMVKREDSWQKRLDKEIEKRRRVEEAYKNAMTELK--KKSHFGGPDYEEGPNSLINEE 319

  Fly   305 EFFDAVETGL---DKIEEDMQLRFKLKLQSQISQTLVNV----------------PHEAVAEGEE 350
            |||||||..|   ||||:....:.:....|.:..|....                |.:.|:..:|
Frog   320 EFFDAVEAALDRQDKIEQSQSEKGRSHWPSSLPSTEAYTTAGSHRFVQAPPSCPPPTDLVSSSDE 384

  Fly   351 AREEFGTGAEATSHALWPEIDRVCKEQLHYAREGVGQDGNGWQIFADEGEIKMYKREEEVNGLVM 415
                         |....:::.:.:..:.|:.:.||.|.| ||:..:|||:|:|:||.|.||:|:
Frog   385 -------------HRFRIQVEEMVQNHMTYSLQDVGGDAN-WQLVVEEGEMKVYRREVEENGIVL 435

  Fly   416 DPLKAYHTVQGVTAREMCHYFFMPEFRNDWETTLEDCTILEKISADTLLFLQTHKRIWPASQRDA 480
            |||||.|:|:|||..|:|.:|:..:.|||||||:|:..::||:|.:.::..|||||:|||||||.
Frog   436 DPLKATHSVKGVTGHEVCQHFWNVDVRNDWETTIENFHVVEKLSPNAIIVYQTHKRVWPASQRDV 500

  Fly   481 QFWSHMRKITDNLEPGA----RDMWVVCNNSTEYAKQESKNGKCVRIFLTVILACQTHL--PEGY 539
            .:.|.:|.:     |.|    .|.|:|||.|.::  ..:...:|||..:.:.:.|||.:  |||
Frog   501 LYLSAIRMV-----PAASENEMDTWIVCNFSVDH--DNAPLNRCVRAKINIAMICQTLVSPPEG- 557

  Fly   540 VKGQPLNRNDLTCKITYCSVVNPGGWAPASALRAVYKREYPKFLKRFTGYVIDQCKDKPIMF 601
              .:.::|:::.|||||.:.||||||||||.||||.||||||||||||.||.::...|.|:|
Frog   558 --NKEISRDNIQCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKSILF 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594	51/89 (57%)
		PH_GPBP	42..142	CDD:270100	53/99 (54%)
		START_STARD11-like	363..601	CDD:176881	110/243 (45%)
cert1	NP_988844.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		6/23 (26%)
		PH_GPBP	26..116	CDD:270100	50/90 (56%)
		FFAT. /evidence=ECO:0000250\|UniProtKB:Q9Y5P4	320..326		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..355		5/22 (23%)
		START_STARD11-like	384..617	CDD:176881	111/256 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I2755
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4173
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1393
OMA	1	1.010	-	-		QHG52378
OrthoDB	1	1.010	-	-		D408116at33208
OrthoFinder	1	1.000	-	-		FOG0006557
OrthoInspector	1	1.000	-	-		oto104392
Panther	1	1.100	-	-	LDO	PTHR10219
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4129
SonicParanoid	1	1.000	-	-		X4792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110