DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cert and Osbp2

DIOPT Version :9

Sequence 1:	NP_001286978.1	Gene:	cert / 38928	FlyBaseID:	FBgn0027569	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_038947935.1	Gene:	Osbp2 / 305475	RGDID:	1310505	Length:	974	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	131/562 - (23%)
Similarity:	214/562 - (38%)	Gaps:	140/562 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTNAGESLGASPPSSN-------EAAAGSQS-------QSDASEEEEYLDNSIEL--------RG 44
            :|.|...| .|||.|.       |:.||.::       ||..|........|:.:        :|
  Rat   109 NTKASPEL-PSPPRSTAESLPKPESKAGPKTQSVLRPGQSKTSAGSPVSGTSVPMVSPPLDSYKG 172

  Fly    45 YLSKWTNYIYGWQPRYIVLKDGTLSYYK----SESESDFG---------CRGAISLTKATIKAHE 96
            :|.|||||:.|:|.|:.||.:|.||||:    ..:||..|         |||.|:|..|..:..:
  Rat   173 WLFKWTNYLKGYQRRWFVLGNGLLSYYRCIQDGITESPLGRNQGEMAHTCRGTINLASAHFETED 237

  Fly    97 SDELRFDVVVNNLNNWCLRAETSEDRMHWVDVLQLYKA-----------DSGSTDTTSLRRHGST 150
            |..:   ::.|....:.|:|.:..||..|:.||:|.||           |||..|
  Rat   238 SCGI---LLCNGARTYHLKASSEVDRQQWITVLELAKAKAIRVMNTQSDDSGDDD---------- 289

  Fly   151 MSLQSNTISLTSGGSLKKTQRNLREKVGELETFKDILFGQIETLQRYFDACSEVNKNNAQPLDLG 215
                ....:......|..|.:.|..|:.:|.|..|::......|||..:....:.    .|.:.|
  Rat   290 ----EEPAAPADNSDLHHTLKTLSLKLDDLGTCNDLIAKHGAALQRSLNELDSLK----IPSESG 346

  Fly   216 DGLKSIDFKGESITFRATTSGVLTTLQHCLEIIAESDESWKRKLEREIDKRRRSEDQSKKLKDEV 280
            :.||.::.:  :..||.|::.::...:..||:.......|:|.|..|.::|...|:..::|..:.
  Rat   347 EKLKVVNER--ATLFRITSNAMINACKDFLELAEIHSRKWQRALNYEQEQRVHLEETIEQLAKQH 409

  Fly   281 EKMKR--LSYPG------PDFEE-------GPHSTLPED-EFFDAVE------TGLDKIEEDMQL 323
            ..::|  .:.||      ..|.|       |.:|...|| |:|||:|      |.:.:.:||..:
  Rat   410 NSLERAFCNTPGGPASSSKSFSEGSFLTSKGENSEEDEDTEYFDAMEDSTSFITVITEAKEDSNI 474

  Fly   324 ------RFKLKLQSQISQTLVNVPHEAVAEGEEAREEFGTGAEATSHALWPEIDRV--------C 374
                  ..::.|.|...:.|.::...|.....||.      |...||...|:..|.        |
  Rat   475 INPYGSATRVNLLSSSPRVLGSIQSTASCPSPEAL------AAWLSHTAHPQAPRARAHQPQCPC 533

  Fly   375 KEQLHYAREGVGQDGNGWQIFAD------EGEIKMYKREEEVNGLVMDP------LKAYHTVQGV 427
            ::    ...|.|.....| ..||      :|...|.|...:|...|..|      |..:..::..
  Rat   534 RK----PEGGPGTTSVDW-TSADNVREVLDGASFMPKDSCKVKRRVRIPDKPNYSLNLWSIMKNC 593

  Fly   428 TAREMCHYFFMPEFRNDWETTLEDCTILEKISADTLLFLQTH 469
            ..||:........|.       |..::|::::.|    |:.|
  Rat   594 IGRELSRIPMPVNFN-------EPLSMLQRLTED----LEYH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cert	NP_001286978.1	PH	40..130	CDD:278594	34/110 (31%)
		PH_GPBP	42..142	CDD:270100	42/131 (32%)
		START_STARD11-like	363..601	CDD:176881	25/127 (20%)
Osbp2	XP_038947935.1	PHA03247	<25..161	CDD:223021	14/52 (27%)
		PH_OSBP_ORP4	170..278	CDD:270101	38/110 (35%)
		Oxysterol_BP	585..960	CDD:395990	8/51 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910