DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E3 and ife-5

DIOPT Version :9

Sequence 1:	NP_648194.1	Gene:	eIF4E3 / 38923	FlyBaseID:	FBgn0265089	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_001379255.1	Gene:	ife-5 / 174871	WormBaseID:	WBGene00002063	Length:	201	Species:	Caenorhabditis elegans

Alignment Length:	176	Identity:	63/176 - (35%)
Similarity:	104/176 - (59%)	Gaps:	11/176 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 HPLEHTWTLWHLENDRTKRWAEMLVDVTSFNTVEDFFSVYYFVKPPSDLKIFNDYMVFKKNIRPM 131
            :||:..|:.|.|.:||...|.:.|..|.:||||.:|::.|..:.|||.|....||.||:.:|:|.
Worm     9 YPLQRNWSWWFLNDDRNASWQDRLKKVYTFNTVPEFWAFYEAILPPSGLNDLCDYNVFRDDIQPK 73

  Fly   132 WEDDTNKNGGRWILLLDKA-SRTYIDKMWHDLLLCMIGECF-QHSDEICGVVINVRNKANKLSLW 194
            ||...|.:||||:::::|. :...:|.:|.::||.:|||.| :..:.|||:|.|||.:.:|:|:|
Worm    74 WEAPENWDGGRWLIIINKGKTPEVLDAVWLEILLALIGEQFGKDMESICGLVCNVRGQGSKISVW 138

  Fly   195 TKDSRNVEAILSIGRQIKELLHLGIME---------IQYQVHKDAM 231
            ||:..:.:..:.||..:||.|.....:         |.||.|::.:
Worm   139 TKNCNDDDTNMRIGVVLKEKLMAAASKAHSKPLFDVIHYQTHRNCV 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E3	NP_648194.1	IF4E	71..224	CDD:279921	58/163 (36%)
ife-5	NP_001379255.1	IF4E	10..159	CDD:396291	58/148 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860