DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT86 and LamC

DIOPT Version :9

Sequence 1:	XP_005268923.1	Gene:	KRT86 / 3892	HGNCID:	6463	Length:	563	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	117/473 - (24%)
Similarity:	202/473 - (42%)	Gaps:	112/473 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   146 GVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKL 210
            |...|:.|..|:                      :|:|||:::.||.|.|.:||::|.||.:|..
  Fly    31 GATSPTSPTRTS----------------------RQQEKEELQHLNDRLACYIDRMRNLENENSR 73

Human   211 LETKLQFYQ---NRECCQSNLEPLFEGYI--------ETLRREAECVEADSGRLASE-------- 256
            |..:|...|   |||  .|||:.::|..:        ||.:.:|: :|.|..||..|
  Fly    74 LTQELNLAQDTVNRE--TSNLKAVYEKELAAARKLLDETAKEKAK-LEIDIKRLWEENDDLKPRL 135

Human   257 -----------------LNHVQEVLEGY------KKKYEEEVSLRATAENEFVA-----LKKDVD 293
                             .|...||...|      :||:|::.. ....|||.:.     |:|.::
  Fly   136 DKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAK-ELALENERLRRQLDDLRKQLE 199

Human   294 CAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQS--HISDTSVVVKLDNSRDLNMDCIIAEIK 356
            ...|.:.|||...::|.:|:.|..:::.:|:...:|  .|..:.:..:|....:..:...:.|::
  Fly   200 AETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELR 264

Human   357 AQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNS 421
            .||:..:..:|.|.|..|.::.:.:||...|..:......||:..:...|..|.|:::|.:..|:
  Fly   265 DQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNA 329

Human   422 KLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRL 486
            .|.|.:.:.|...:.........:|.||..||:.:.:||..::|||.:|:.|:.||:|||.|.:|
  Fly   330 GLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKL 394

Human   487 LEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSA 551
            |.|||:||                         :..:|...|..|.:.||.:.:  |.:|.:.|.
  Fly   395 LCGEERRL-------------------------NIESPGRPTTDSGISSNGSHL--TASASSRSG 432

Human   552 RV----------GVCGGS 559
            ||          |:.|.|
  Fly   433 RVTPSGRRSATPGISGSS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT86	XP_005268923.1	Keratin_2_head	<80..179	CDD:292825	4/32 (13%)
		Filament	182..493	CDD:278467	97/359 (27%)
		Prefoldin	302..417	CDD:298833	25/116 (22%)
		RILP-like	<392..>460	CDD:304877	15/67 (22%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	97/359 (27%)
		ATP-synt_B	<67..>142	CDD:304375	21/77 (27%)
		MreC	<178..>224	CDD:302802	12/46 (26%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910