Protein Alignment UbcE2M and UBE2D2

DIOPT Version :10

• Sequence 1: NP_648187.1
• Gene: UbcE2M / 38916
• FlyBaseID: FBgn0035853
• Length: 181
• Species: Drosophila melanogaster
• Sequence 2: XP_047273646.1
• Gene: UBE2D2 / 7322
• HGNCID: 12475
• Length: 173
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 134/743 - (18%)
• Similarity: 235/743 - (31%)
• Gaps: 252/743 - (33%)

  Fly    25 SYTHNLEKNLVALETTMEELKAKRDDLLRKLKREEDRGLQTLGEIKVWLNRVETIESRVNDLLNA 89
            ||.:.:.|.::   ..:.:|..:....:||.::::.|.|:.:|...|.|..::....:..|   .
Human  1171 SYNYRVVKEIL---IRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAED---T 1229

  Fly    90 RNAELQRLC---LCGFCSKSLTTSYRYGKSVFLKLREVEKLERRVFEVISDQ-------ASTSEV 144
            :..|:.||.   |..||:.:........|.:.|.|..      .:.|.::.|       ...||:
Human  1230 KMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNP------GILEAVTMQHIFMNNFQLCSEI 1288

  Fly   145 EEQQLQ-------------------PTIVGQETML-----DNAWNHLMEDGVGIMGLYG------ 179
            .|:.:|                   .|||..|...     |.....|:..|..::..|.
Human  1289 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQ 1353

  Fly   180 -------------------MGGVGKTTLL---TQINNKFSKYMCG----FDSVIWVVVSK----E 214
                               |..:....||   |:..|.:::..|.    .|.::.||..:    |
Human  1354 TLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPE 1418

  Fly   215 VNVENILDEIAQKVHISGEKWDTKYKYQKGVYLYNFLRKMRFVLFLDDIWEKVN----------- 268
            |.:..|  ......::     ||:.: .|.:|..|.:.|: |..||.||....|
Human  1419 VKIAYI--NFLNHCYV-----DTEVE-MKEIYTSNHMWKL-FENFLVDICRACNNTSDRKHADSI 1474

  Fly   269 ----LVEIGVPFPTIKNKCKVVFTTRSLDVCTSMGVEKPMEVQCLADNDAYDLF--------QKK 321
                :.||.:...|      ..|::...|..|::...:|:.||.|  ...:.::        ||
Human  1475 LEKYVTEIVMSIVT------TFFSSPFSDQSTTLQTRQPVFVQLL--QGVFRVYHCNWLMPSQK- 1530

  Fly   322 VGQITLGSDPEIRELSRVVAKKCCGLPLALNVVSETMSCK------RTVQEWRHAI--------- 371
                 ...:..||.||.|...:...:|:.|:.....:..|      :|...||.:.
Human  1531 -----ASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSV 1590

  Fly   372 --------YVLNSYAAKFSGMDDKILPL----LKYSYDSLKGEDVKMCLLYCALFPEDAKIRKEN 424
                    .::.......|.::|::.||    |....|.|...::        ||||:...|:
Human  1591 LAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPEL--------LFPENTDARR-- 1645

  Fly   425 LIEYWICEEIIDGSEGIDKAENQGYEIIGSLVR-ASLLMEEVELDGANIVCLHDVVREMALWIAS 488
                              |.|:.|:  |..|:: ...|:||.|
Human  1646 ------------------KCESGGF--ICKLIKHTKQLLEENE---------------------- 1668

  Fly   489 DLGKQNEAFIVRASVGLREILKVENWNVVRRMSLMKNNIAHLDGRLDCMELTTLLLQSTHLEKIS 553
                  |...::....|||::..:.....:.:|:         ..||..||.    .:...|..:
Human  1669 ------EKLCIKVLQTLREMMTKDRGYGEKLISI---------DELDNAELP----PAPDSENAT 1714

  Fly   554 SEFFNSMPKLAVLD-----------LSGNYYLSELPNGISE-LVSLQYLNLSS------------ 594
            .:.....|.|..|:           |...||.:..|:|..| |.|.....||:
Human  1715 EQELEPSPPLRQLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGG 1779

  Fly   595 TGIRHLPKGLQELKKL-IHLYLERTSQL 621
            :|...:.:|...|.:: .||..|..|.|
Human  1780 SGSSSMSRGEMSLAEVQCHLDKEGASNL 1807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UbcE2M	NP_648187.1	UBCc_UBE2F_UBE2M	26..163	CDD:467414	31/170 (18%)
UBE2D2	XP_047273646.1	UBCc_UBE2D	35..171	CDD:467412