DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7387 and Dnaja3

DIOPT Version :9

Sequence 1:	NP_648186.3	Gene:	CG7387 / 38915	FlyBaseID:	FBgn0035852	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_076135.3	Gene:	Dnaja3 / 83945	MGIID:	1933786	Length:	480	Species:	Mus musculus

Alignment Length:	433	Identity:	131/433 - (30%)
Similarity:	204/433 - (47%)	Gaps:	54/433 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATDCCRKTSHCLELDRAPAVAACWICMRMISQYQFRTTKPAYYPDRQREAKRTSAGATPQQVSSP 86
            ||..|||.          .|:|..:.|.........|.:|.        .:.|...:.|...::
Mouse    36 ATSLCRKL----------CVSAFGLSMGAHGPRALLTLRPG--------VRLTGTKSFPFVCTT- 81

  Fly    87 AVKYPQSRGMPKDYYYKVLGVNRHATIQQIRSAFYALAKRYHPDSTHSEQKLKH-FQELSNAYNI 150
              .:..|..:.||.||::|||.|:|:.:.|:.|:|.|||:||||:...:.|.|. |.:|:.||.:
Mouse    82 --SFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEV 144

  Fly   151 LTDETKRLEYDQLG--GIKDERAFLEQA---GNPLNVGLEEAKKFDSDKTTNDEINKLKSNEFDL 210
            |:||.||.:||..|  |.....:...|.   |.| :|..||..:....:.::......: |.||.
Mouse   145 LSDEVKRKQYDAYGSAGFDPGTSSSGQGYWRGGP-SVDPEELFRKIFGEFSSSPFGDFQ-NVFDQ 207

  Fly   211 P------LDFLEATVGCKKRIELRYLRKCETCKGKSQLMAHRDVGKEP------CRRCNGTGKVM 263
            |      |.|.:|..|..|...:..:..||.|.||         |.||      |..|.|:|...
Mouse   208 PQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGK---------GNEPGTKVQHCHYCGGSGMET 263

  Fly   264 TKTPTFSSVNTCTQCKGKRFTNRNDCETCSNRGFVVSNVDVMVSVPSGSRDGDVVNIINPETKQQ 328
            ..|..|...:||.:|.|:.....|.|..|...|.......|.:.||:|..||..|.:  |..|::
Mouse   264 INTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTIPVPAGVEDGQTVRM--PVGKRE 326

  Fly   329 VTYRLSVPSSDYFRRVGNDILTDKHLNISEAILGGSFQIRGLYESVELRVEPGTQSHTQVVLNGK 393
            :.....|..|..|||.|.||.:|..::|::|||||:.:.:||||::.:.:..|.|:..::.|.||
Mouse   327 IFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGK 391

  Fly   394 GVR--SREGVGNHIVTLKVRIPRNLSVKQRQLVLALSQAEDPV 434
            |:.  :..|.|:|.:.:|:|:|:.||.:|:.|:|:.::.|..|
Mouse   392 GIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDV 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7387	NP_648186.3	DnaJ_bact	101..431	CDD:274090	114/349 (33%)
		DnaJ	101..161	CDD:278647	28/60 (47%)
		DnaJ_zf	233..296	CDD:199908	21/68 (31%)
		DnaJ_C	298..416	CDD:199909	40/119 (34%)
Dnaja3	NP_076135.3	DnaJ	90..480	CDD:223560	118/358 (33%)
		DnaJ	93..155	CDD:278647	28/61 (46%)
		DnaJ_C	207..416	CDD:199909	68/219 (31%)
		DnaJ_zf	236..296	CDD:199908	21/68 (31%)
		CXXCXGXG motif	236..243		5/15 (33%)
		CXXCXGXG motif	253..260		3/6 (50%)
		CXXCXGXG motif	275..282		3/6 (50%)
		CXXCXGXG motif	289..296		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1730
OMA	1	1.010	-	-		QHG53632
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001676
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44145
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.830