DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7387 and CG5504

DIOPT Version :9

Sequence 1:	NP_648186.3	Gene:	CG7387 / 38915	FlyBaseID:	FBgn0035852	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_995932.1	Gene:	CG5504 / 48844	FlyBaseID:	FBgn0002174	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	134/444 - (30%)
Similarity:	213/444 - (47%)	Gaps:	60/444 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CRKTSHCLELDRAPAVAACWICMRMISQYQFRTTKPAYYPDRQREAKRTSAGATPQQVSSPAV-K 89
            |:|.....:|   |||..|      ::...|.|.:...|      ...:|||:...:..:|.| :
  Fly     5 CKKLFVFRQL---PAVRRC------LAAAAFSTPRATSY------RILSSAGSGSTRADAPQVRR 54

  Fly    90 YPQSRGMPKDYYYKVLGVNRHATIQQIRSAFYALAKRYHPDSTHSEQKL-KHFQELSNAYNILTD 153
            ...:|.:....||..|||.::|..:.|:.|:|.|||:||||:...:... :.|||:|.||.:|:|
  Fly    55 LHTTRDLLAKDYYATLGVAKNANGKDIKKAYYQLAKKYHPDTNKEDPDAGRKFQEVSEAYEVLSD 119

  Fly   154 ETKRLEYDQLGGIKDERAFLEQAGNPLN-------VGLEEAKKFDSDKTTNDEINKL------KS 205
            |.||.|||..|... |....:..|.|..       .|..::.:|.|.....:...|:      ::
  Fly   120 EQKRREYDTYGQTA-ENIGRQGGGFPGGGAGGFGPEGFSQSWQFRSSIDPEELFRKIFGEGNFRT 183

  Fly   206 NEFD----------------LPLDFLEATVGCKKRIELRYLRKCETCKGKSQLMAHRDVGKEP-- 252
            |.||                :.|.|.:|..|..|.:.:..:.:|..|.|     ...:.|.:|
  Fly   184 NSFDDFADSKFGFGQAQEMVMDLTFAQAARGVNKDVNVNVVDQCPKCAG-----TKCEPGTKPGR 243

  Fly   253 CRRCNGTGKVMTKTPTFSSVNTCTQCKGKRFTNRNDCETCSNRGFVVSNVDVMVSVPSGSRDGDV 317
            |:.|||||.....|..|...:||..|:|.|...:..|..|..:|..|....|.|.||:|..:|..
  Fly   244 CQYCNGTGFETVSTGPFVMRSTCRYCQGTRQHIKYPCSECEGKGRTVQRRKVTVPVPAGIENGQT 308

  Fly   318 VNIINPETKQQVTYRLSVPSSDYFRRVGNDILTDKHLNISEAILGGSFQIRGLYESVELRVEPGT 382
            |.:.....:..||:|  |..||||||.|.|:.||..:::::|:|||:.:::|:||...:.|||||
  Fly   309 VRMQVGSKELFVTFR--VERSDYFRREGADVHTDAAISLAQAVLGGTVRVQGVYEDQWINVEPGT 371

  Fly   383 QSHTQVVLNGKGVR--SREGVGNHIVTLKVRIP--RNLSVKQRQLVLALSQAED 432
            .||.:::|.|||::  :..|.|:|.|.:|:.:|  :.|..|:..|:.|.::.|:
  Fly   372 SSHHKIMLRGKGLKRVNAHGHGDHYVHVKITVPSAKKLDKKRLALIEAYAELEE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7387	NP_648186.3	DnaJ_bact	101..431	CDD:274090	117/365 (32%)
		DnaJ	101..161	CDD:278647	28/60 (47%)
		DnaJ_zf	233..296	CDD:199908	20/64 (31%)
		DnaJ_C	298..416	CDD:199909	46/121 (38%)
CG5504	NP_995932.1	DnaJ	63..437	CDD:223560	118/371 (32%)
		DnaJ	65..127	CDD:278647	28/61 (46%)
		DnaJ_zf	227..287	CDD:199908	20/64 (31%)
		DnaJ_C	288..409	CDD:199909	46/122 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440490
Domainoid	1	1.000	91	1.000	Domainoid score	I1749
eggNOG	1	0.900	-	-		E2759_KOG0715
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1730
OMA	1	1.010	-	-		QHG53632
OrthoDB	1	1.010	-	-		D436402at33208
OrthoFinder	1	1.000	-	-		FOG0001676
OrthoInspector	1	1.000	-	-		otm46487
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44145
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.810