DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED24 and med24

DIOPT Version :9

Sequence 1:	NP_648185.1	Gene:	MED24 / 38914	FlyBaseID:	FBgn0035851	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001034151.1	Gene:	med24 / 323621	ZFINID:	ZDB-GENE-030131-2341	Length:	989	Species:	Danio rerio

Alignment Length:	1026	Identity:	290/1026 - (28%)
Similarity:	515/1026 - (50%)	Gaps:	96/1026 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKENNKILQLIYVAWRERWTDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYL 65
            ||..| :.|.|..||:|||:|.||.|||||..|:|.:.|..|||:.|::||:||.:.|||:|:||
Zfish     1 MKVVN-LKQAILQAWKERWSDYQWAINIKKNCPKGATWDYLNLAEALLEQAMIGPSPNPLILSYL 64

  Fly    66 KHSLCAHLVSHAAVIRCIAKYDKLERVYCITALLEFLASIVDGVTCRIKSEEAV-LPSSVVHLVY 129
            |:::.:.:||:::|:..|:|:|...|..|:.:|||.:....:.::|..|:||.: |..:::..|.
Zfish    65 KYAISSQMVSYSSVLTAISKFDDFSRELCVKSLLEIMDMFSNRLSCHGKAEECIGLCRAMLCTVV 129

  Fly   130 WLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLSQQQFLLSMLYVGCHEELEICGRIRD-- 192
            ||||..|...:......:.||.:|.:  :.|  ::|::      ::|:...:..|....|:.:
Zfish   130 WLLQGCAWYCERLRDPNDFSALESSL--RAC--LERMA------NLLHSTKNRALVHIARLEEQA 184

  Fly   193 -----KYATIKGSLTNSNFTLNAPQVEQQLQQLAFIEAKHLEMQPL--NPP--STLEKISCCVQP 248
                 :.|.:|  ||.:...:..|.:::.|::...:.....:|..|  :||  :|...    |..
Zfish   185 SWTNVEQAVLK--LTENLSAVTNPTLKESLEECVSLVKSIPQMLCLQCDPPVHTTFPS----VHA 243

  Fly   249 LLAVEVLLNPCKDTSYYVAELQMLQRLKKYSNTRLFYEIIRAGFLTLSNVADTSPDTMWGAFMFF 313
            .:.:|..:|...:|...|.:|.|::|:::.........|.:|.|..|....:.:.:..|.||.|.
Zfish   244 FIMLEGTMNLTGETQPLVEQLMMIKRMQRIPAPLFVLGIWKACFTGLIESPEGNEELKWTAFTFL 308

  Fly   314 KMPHIIKQLHALQRIP-GEQPPPADYIPELVEALELLIEDNLLLDFMDTKCSCNMIEFLLNDWTK 377
            |:|.::.:   |::.| ||:  ..|:..::..|.|.|:....|||..|.:|:|:.:..||.:..|
Zfish   309 KIPQVLLR---LKKYPQGEK--TQDFTEDVNVAFEYLLNLTPLLDKADQRCNCDCLSLLLQECNK 368

  Fly   378 QQLVNDVH----VKKFASQREAASQLLKKCDNGQQTPSNINFIKRAEVPLSGVLKTL---CTNKV 435
            ..|:::.:    ..|.:..||.|.: ||..:|....| |...|.|||..::.:|||:   .:...
Zfish   369 LGLLSEANTATLTAKRSEDREHAPR-LKTAENANIQP-NPGLILRAEPTVTNILKTVDADHSKSP 431

  Fly   436 QDMVNVLCQVPVGNSFELILSVATVEGRLKTFVSRLIQCNENSKPVPGDLGKLCVIRSTLFDVSF 500
            :.::.||..:..|.|.:|:|:.|...|:||:|..:.|:.||..|.:.|:..|...:|:.|||:||
Zfish   432 EGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISF 496

  Fly   501 LMLTSIVQTYGSDVVLSERGDS----FFEKWVRECMVERNKLKNPRQILALCDDSIVDELLLSFS 561
            |||..:||||||:|:||:...|    |||.|::.||.|..|..||.......:...|:.|:...:
Zfish   497 LMLCHVVQTYGSEVILSDPSPSSETPFFETWLQTCMPEEGKTLNPDHPCFRPESGKVESLVALLN 561

  Fly   562 KPEASQLKPNNLSWQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSVCATSFLC 626
              .:|::|...:.|.|.||:.|..:..||.|||...||...|:.|.||||.::.|.::||.::|.
Zfish   562 --SSSEMKLVQMKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLV 624

  Fly   627 AYMYSVKETELLKPLNMIQQFLAPLTSEELSSQENAKERLALSYQIIRKMQHDV----------- 680
            |::..:...|..||..||:|.:.|::.|  ::.:...||:.:...|:..|..||
Zfish   625 AHVRMLGLDEREKPQTMIRQLMTPMSGE--NTLQFYHERVVIMSSILEHMCADVFQQTGLSLRPA 687

  Fly   681 ----HPAPSTKSRLISHSPLVEQFREVWRTVVDAGHLPVRAAQSLESLLLAGGAAWLSTQLVEQL 741
                .|.| .::.|.:..|:.:..:..:|.|::.|.:...|....|:||..||..|.:..||::|
Zfish   688 VEGQEPIP-YRNLLPARLPIRQALQSQFRKVLEKGWVDSHAFHLFENLLHMGGVFWFTNNLVKEL 751

  Fly   742 LACKYTRD--MSRTMDVVFAVMHLDIEKTTEALLQYVVAPLIL-RRQGEDINEPQSLVLARLCVY 803
            |  |.||.  .||.:::::::..||.::.|..||.:::..|:. ......:.:|....||:|.|:
Zfish   752 L--KETRKEWASRVVELLYSIFCLDTQQITLTLLGHILPRLLTDPAHWHSLADPPGRALAKLSVW 814

  Fly   804 CIISCLESRKGNGTSALTAMKKRSRSHDD-EELAA-------NAAKVRKVIGDGSDNSSDFTDTT 860
            |.:|...|......||    ::|.|..:| |:..:       ..:|:.:::....|.:|    ..
Zfish   815 CALSSYSSHHKGQASA----RQRKRHREDIEDYTSLFPLDDTQPSKLMRLLSSNEDENS----ML 871

  Fly   861 TGAGLAALLGSTSTSELRTTPLTLREPLQTSVQHIFAVFLQFVSGDELSPKAVFVYQFISLLVEC 925
            :..|..::..|.|.|:|.|  :.:|:||...:.::|.:....:......|...||..|:...|:|
Zfish   872 SSPGDRSISSSLSASQLHT--VNMRDPLNRVLANLFLLISSQLGSKTAGPHTQFVQSFVEECVDC 934

  Fly   926 G--GERVAPVLRLLPNGLVQQLLKVLVTDDIKVGLISRLYDLRIQAGRLSA 974
            .  |.| :.:|:.:|..::.:|:|  :....|...:..:.||.:..||..|
Zfish   935 SEQGSR-SSILQFMPFTMISELVK--LQSLAKPKTVLSITDLSLPLGRRMA 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED24	NP_648185.1	Med24_N	3..979	CDD:288171	288/1024 (28%)
med24	NP_001034151.1	Med24_N	1..987	CDD:288171	290/1026 (28%)
		LXXLL motif 1	343..347		0/3 (0%)
		LXXLL motif 2	359..363		0/3 (0%)
		LXXLL motif 3	447..451		1/3 (33%)
		LXXLL motif 4	556..560		1/3 (33%)
		LXXLL motif 5	787..791		0/3 (0%)
		LXXLL motif 6	857..861		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596769
Domainoid	1	1.000	376	1.000	Domainoid score	I828
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40795
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2055
OMA	1	1.010	-	-		QHG45577
OrthoDB	1	1.010	-	-		D323841at33208
OrthoFinder	1	1.000	-	-		FOG0007958
OrthoInspector	1	1.000	-	-		oto40262
orthoMCL	1	0.900	-	-		OOG6_107547
Panther	1	1.100	-	-	LDO	PTHR12898
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4645
SonicParanoid	1	1.000	-	-		X5901
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940