Protein Alignment Atg18a and ATG18

DIOPT Version :9

• Sequence 1: NP_001261565.1
• Gene: Atg18a / 38913
• FlyBaseID: FBgn0035850
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_444297.1
• Gene: ATG18 / 850577
• SGDID: S000001917
• Length: 500
• Species: Saccharomyces cerevisiae
• Alignment Length: 497
• Identity: 125/497 - (25%)
• Similarity: 214/497 - (43%)
• Gaps: 151/497 - (30%)

  Fly    16 FVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLIERLFESSLVAIVS-----QR 75
            |:||||..|.:::.||.|:.:::.    ....|.|...|....::|.||.:||:|:|.     ..
Yeast    10 FINFNQTGTCISLGTSKGFKIFNC----EPFGKFYSEDSGGYAIVEMLFSTSLLALVGIGDQPAL 70

  Fly    76 APRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCNPQ 140
            :||:|::.:.||.|.||..::..:||:||:|:.||:|.|:|.:||::|..|:::|||...| ||:
Yeast    71 SPRRLRIINTKKHSIICEVTFPTSILSVKMNKSRLVVLLQEQIYIYDINTMRLLHTIETNP-NPR 134

  Fly   141 GLCALSSSSEHCYLAYPGS---------------------------------------------- 159
            ||.|:|.|..:.||.||..
Yeast   135 GLMAMSPSVANSYLVYPSPPKVINSEIKAHATTNNITLSVGGNTETSFKRDQQDAGHSDISDLDQ 199

  Fly   160 ----------------------VTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATAS 202
                                  :..|:|.:|:...|....:|.||...:||:|.|..||.:||||
Yeast   200 YSSFTKRDDADPTSSNGGNSSIIKNGDVIVFNLETLQPTMVIEAHKGEIAAMAISFDGTLMATAS 264

  Fly   203 ERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRLDRSAT---- 263
            ::||:||||..:.|.::::.||| .....|.|:|||..::||..:.:::|||||:|..|.:
Yeast   265 DKGTIIRVFDIETGDKIYQFRRG-TYATRIYSISFSEDSQYLAVTGSSKTVHIFKLGHSMSNNKL 328

  Fly   264 ETAEGHGSKQSSDD-------------------------------WMG----YS---FFRFLSKT 290
            ::.:.:..:.::||                               .||    ||   ..|..::|
Yeast   329 DSDDSNMEEAAADDSSLDTTSIDALSDEENPTRLAREPYVDASRKTMGRMIRYSSQKLSRRAART 393

  Fly   291 VTSYLPTQVTDVFSQGRAFASVTLPEAGVRRMCAIATI--------------------------- 328
            :....|.:||.:....|.|||:.||......:..|::|
Yeast   394 LGQIFPIKVTSLLESSRHFASLKLPVETNSHVMTISSIGSPIDIDTSEYPELFETGNSASTESYH 458

  Fly   329 ---QKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLE 367
               .|.:.:.:.|.|||||.:.:....|.:|.::.::.:.::
Yeast   459 EPVMKMVPIRVVSSDGYLYNFVMDPERGGDCLILSQYSILMD 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	99/369 (27%)
		WD40	23..269	CDD:295369	92/322 (29%)
		WD40 repeat	143..180	CDD:293791	11/104 (11%)
		WD40 repeat	186..231	CDD:293791	20/44 (45%)
		WD40 repeat	232..258	CDD:293791	12/25 (48%)
ATG18	NP_444297.1	WD40	<224..318	CDD:421866	38/94 (40%)
		WD40 repeat	249..285	CDD:293791	17/35 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90887
Inparanoid	1	1.050	195	1.000	Inparanoid score	I885
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	1	1.000	-	-		mtm9229
orthoMCL	1	0.900	-	-		OOG6_103112
Panther	1	1.100	-	-	LDO	PTHR11227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830