DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18a and ATG18B

DIOPT Version :9

Sequence 1:	NP_001261565.1	Gene:	Atg18a / 38913	FlyBaseID:	FBgn0035850	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001320091.1	Gene:	ATG18B / 829174	AraportID:	AT4G30510	Length:	366	Species:	Arabidopsis thaliana

Alignment Length:	356	Identity:	106/356 - (29%)
Similarity:	183/356 - (51%)	Gaps:	51/356 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VNFNQNITSLAVATSGGYSLYSLGSVDSTLDKI-YHTKSDELFLIERLFESSLVAIV-----SQR 75
            |:|||:.:..|::....:.::     |||..:: |...:....::|.|:.|.|:|||     :..
plant    14 VSFNQDNSGFAISWKDSFKIF-----DSTTGRLCYERAAGAFVIVEMLYSSDLLAIVGAGEQASL 73

  Fly    76 APRKLKVCHFKKQS--EICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCN 138
            :||:|  |.||..:  .:...::..:||||::|::||:|.|.|..:::::..:.::.|| ||..|
plant    74 SPRRL--CLFKTTTGLPLRELNFLTSILAVRMNKKRLVVVLLEKTFVYDLNTLVMLDTI-DTVPN 135

  Fly   139 PQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASE 203
            |:||.|.|.|.|.||||.|.|.|.|.|.:::.::|.:.:.|.||.:||||:|.|.:|..|||.||
plant   136 PKGLSAFSPSLEGCYLAVPASTTKGSVLVYNVMDLQSHSEIDAHRSPLAAIALSSNGMYIATGSE 200

  Fly   204 RGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSF---STCAEYLVSSSNTETVHIFRLDRSATET 265
            :||:|||....:.::.:..|||.... :|.||||   :...:.|:::|::.::|.|.|..:..:.
plant   201 QGTLIRVHLVSEATKSYSFRRGTYPS-TIYSLSFGPSTQLPDILIATSSSGSIHAFSLSLAINQR 264

  Fly   266 AEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTLPEAGVRRMCAIATIQK 330
                 ||:|:.         ||.    |.||..|:|...............:|:|....:..|.|
plant   265 -----SKRSTS---------FLG----SVLPDSVSDALDPAHHHVLQNAVSSGIRSYAVVRKIDK 311

  Fly   331 -----------QLRLLIA--SQDGYLYVYSI 348
                       .||..::  :.:||...|::
plant   312 LEGTSSPSHFTSLRATVSVITYNGYFQEYTL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	90/271 (33%)
		WD40	23..269	CDD:295369	83/256 (32%)
		WD40 repeat	143..180	CDD:293791	14/36 (39%)
		WD40 repeat	186..231	CDD:293791	19/44 (43%)
		WD40 repeat	232..258	CDD:293791	9/28 (32%)
ATG18B	NP_001320091.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90887
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D1216824at2759
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103112
Panther	1	1.100	-	-	LDO	PTHR11227
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790