DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18a and AtATG18a

DIOPT Version :9

Sequence 1:	NP_001261565.1	Gene:	Atg18a / 38913	FlyBaseID:	FBgn0035850	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_567132.4	Gene:	AtATG18a / 825452	AraportID:	AT3G62770	Length:	425	Species:	Arabidopsis thaliana

Alignment Length:	363	Identity:	103/363 - (28%)
Similarity:	177/363 - (48%)	Gaps:	42/363 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDE---LFLIERLFESSLVAIVS----- 73
            ::|||:....||.|..|:.:.:.    ....:|:....|.   :.::|.||..:::|:|.
plant    81 LSFNQDHACFAVGTDRGFRILNC----DPFREIFRRDFDRGGGVAVVEMLFRCNILALVGGGPDP 141

  Fly    74 QRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRDTPCN 138
            |..|.|:.:....:...|...|:.:.:.:|:|.|:|:||.||:.::::|..|:|::|.| :|..|
plant   142 QYPPNKVMIWDDHQGRCIGELSFRSDVRSVRLRRDRIIVVLEQKIFVYNFSDLKLMHQI-ETIAN 205

  Fly   139 PQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIATASE 203
            |:||||:|.......|..|| :..|:|:|....:...| .:.|||:.:|..|.:..|..:||||.
plant   206 PKGLCAVSQGVGSMVLVCPG-LQKGQVRIEHYASKRTK-FVMAHDSRIACFALTQDGHLLATASS 268

  Fly   204 RGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRLDRSATETAEG 268
            :||::|:|::.||:...|:|||..| ..|.||:||:.|::|..||:..|||:|.|     :...|
plant   269 KGTLVRIFNTVDGTLRQEVRRGADR-AEIYSLAFSSNAQWLAVSSDKGTVHVFGL-----KVNSG 327

  Fly   269 HGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDV--------FSQGRAFASVTLPEAGVRRMCAI 325
            ...|.||.          ::...|...|:....:        ||...:.|...|.| |.:.:.|.
plant   328 SQVKDSSR----------IAPDATPSSPSSSLSLFKGVLPRYFSSEWSVAQFRLVE-GTQYIAAF 381

  Fly   326 ATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHD 363
            .  .::..::|...||..|......|.|.|...::.|:
plant   382 G--HQKNTVVILGMDGSFYRCQFDPVNGGEMSQLEYHN 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	86/268 (32%)
		WD40	23..269	CDD:295369	79/253 (31%)
		WD40 repeat	143..180	CDD:293791	10/36 (28%)
		WD40 repeat	186..231	CDD:293791	18/44 (41%)
		WD40 repeat	232..258	CDD:293791	13/25 (52%)
AtATG18a	NP_567132.4	WD40	<134..320	CDD:421866	67/189 (35%)
		WD40 repeat	169..204	CDD:293791	14/35 (40%)
		WD40 repeat	209..246	CDD:293791	11/38 (29%)
		WD40 repeat	254..288	CDD:293791	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920