DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18a and Wipi2

DIOPT Version :9

Sequence 1:	NP_001261565.1	Gene:	Atg18a / 38913	FlyBaseID:	FBgn0035850	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_848485.1	Gene:	Wipi2 / 74781	MGIID:	1923831	Length:	445	Species:	Mus musculus

Alignment Length:	453	Identity:	238/453 - (52%)
Similarity:	309/453 - (68%)	Gaps:	41/453 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MSLLGRT-DVDAGE-VFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYH-TKSDELFLIERL 63
            |:|..:: :..||: :|.||||:.|||||.:..||..:||.|||. |::||. |.::::.::|||
Mouse     1 MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDK-LEQIYECTDTEDVCIVERL 64

  Fly    64 FESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKV 128
            |.||||||||.:||||||||||||.:|||||||:||||||||||:|||||||||||||||:||||
Mouse    65 FSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKV 129

  Fly   129 VHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSP 193
            :||||:||.||.||||||.::::||||||||.:.||||:||.|||.|..||||||:|||||||..
Mouse   130 LHTIRETPPNPAGLCALSINNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDA 194

  Fly   194 SGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRL 258
            |||::|||||:||||||||..:|.:|||.|||:||||||.||:||....:|.:||||||||||:|
Mouse   195 SGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL 259

  Fly   259 DRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTLPEAGVRRMC 323
            :....:..|      ....|.|| |.:.|..: |||||:|||::|:||||||:|.||..|.:.:|
Mouse   260 EAVREKPPE------EPTTWTGY-FGKVLMAS-TSYLPSQVTEMFNQGRAFATVRLPFCGHKNIC 316

  Fly   324 AIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDL--------RLEDHYAMDIKVDSPQ 380
            ::.||||..|||:.:.|||||:|::...||.||.|:::|.|        .:.|..:.|..: :.|
Mouse   317 SLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPL-ATQ 380

  Fly   381 TLGLNSGVSIGGAAGVPPSSASAAGAG-----------TGGSGG----DGKSAVSVTGGVDKP 428
            |.|     :........|||.:..|.|           .|..||    |..||:.:....:.|
Mouse   381 TYG-----TAAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	172/263 (65%)
		WD40	23..269	CDD:295369	167/246 (68%)
		WD40 repeat	143..180	CDD:293791	23/36 (64%)
		WD40 repeat	186..231	CDD:293791	32/44 (73%)
		WD40 repeat	232..258	CDD:293791	16/25 (64%)
Wipi2	NP_848485.1	WD40 repeat	18..53	CDD:293791	19/35 (54%)
		WD40	<21..272	CDD:225201	169/257 (66%)
		WD40 repeat	58..94	CDD:293791	26/35 (74%)
		WD40 repeat	102..134	CDD:293791	28/31 (90%)
		WD40 repeat	143..182	CDD:293791	25/38 (66%)
		WD 1. /evidence=ECO:0000255	182..222		28/39 (72%)
		WD40 repeat	188..228	CDD:293791	28/39 (72%)
		FRRG motif. /evidence=ECO:0000303\|PubMed:24954904	223..226		1/2 (50%)
		WD 2. /evidence=ECO:0000255	228..267		22/38 (58%)
		WD40 repeat	233..266	CDD:293791	17/32 (53%)
		WD40 repeat	274..309	CDD:293791	21/36 (58%)
		WD 3. /evidence=ECO:0000255	311..349		17/37 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	423	1.000	Domainoid score	I624
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90887
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1756
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	1	1.000	-	-		otm43483
orthoMCL	1	0.900	-	-		OOG6_103112
Panther	1	1.100	-	-	LDO	PTHR11227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	1	1.000	-	-		X1186
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.900