DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg18a and WDR45B

DIOPT Version :9

Sequence 1:NP_001261565.1 Gene:Atg18a / 38913 FlyBaseID:FBgn0035850 Length:447 Species:Drosophila melanogaster
Sequence 2:NP_062559.2 Gene:WDR45B / 56270 HGNCID:25072 Length:344 Species:Homo sapiens


Alignment Length:392 Identity:107/392 - (27%)
Similarity:178/392 - (45%) Gaps:70/392 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MSLLGRTDVDAGEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFL------I 60
            |:||.......|.::..|||:....|.....|:.:|:...:..        |..:.||      :
Human     1 MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKE--------KEKQEFLEGGVGHV 57

  Fly    61 ERLFESSLVAIVS-----QRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESL-- 118
            |.||..:.:|:|.     :..|.|:.:....|:..:....::..:.||||.|:|::|.|:..:  
Human    58 EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKV 122

  Fly   119 --YIHNIQDMKVVHTIRDTPC-NPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTM-I 179
              :.||...:.|..|     | ||:|||.|..:|.:..||:||:.| |.||:.|..:.....: |
Human   123 FTFTHNPHQLHVFET-----CYNPKGLCVLCPNSNNSLLAFPGTHT-GHVQLVDLASTEKPPVDI 181

  Fly   180 PAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYL 244
            |||:..|:.:|.:..||.||||||:||:||:|.:..|..:.||||| .:..:|..::|:..|..:
Human   182 PAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRG-SQAANIYCINFNQDASLI 245

  Fly   245 VSSSNTETVHIFRLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAF 309
            ..||:..|||||..:       :...:|||             |....|:||    ..||...:|
Human   246 CVSSDHGTVHIFAAE-------DPKRNKQS-------------SLASASFLP----KYFSSKWSF 286

  Fly   310 ASVTLPEAGVRRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDI 374
            :...:| :|...:||..|....:..:.|....|.::::    ...||         :.|.||..:
Human   287 SKFQVP-SGSPCICAFGTEPNAVIAICADGSYYKFLFN----PKGEC---------IRDVYAQFL 337

  Fly   375 KV 376
            ::
Human   338 EM 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg18aNP_001261565.1 WD40 <15..278 CDD:225201 84/279 (30%)
WD40 23..269 CDD:295369 78/262 (30%)
WD40 repeat 143..180 CDD:293791 12/37 (32%)
WD40 repeat 186..231 CDD:293791 21/44 (48%)
WD40 repeat 232..258 CDD:293791 10/25 (40%)
WDR45BNP_062559.2 WD 1 2..38 9/35 (26%)
WD40 <25..258 CDD:421866 77/247 (31%)
WD 2 44..87 10/42 (24%)
WD 3 93..125 8/31 (26%)
WD40 repeat 102..126 CDD:293791 8/23 (35%)
WD 4 130..171 18/46 (39%)
WD40 repeat 145..183 CDD:293791 13/38 (34%)
WD 5 176..215 19/38 (50%)
WD40 repeat 188..225 CDD:293791 17/36 (47%)
WD 6 220..259 15/39 (38%)
WD40 repeat 234..267 CDD:293791 9/39 (23%)
WD 7 265..314 15/66 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54442
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R106
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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