DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18a and Wdr45

DIOPT Version :9

Sequence 1:	NP_001261565.1	Gene:	Atg18a / 38913	FlyBaseID:	FBgn0035850	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001277721.1	Gene:	Wdr45 / 54636	MGIID:	1859606	Length:	360	Species:	Mus musculus

Alignment Length:	390	Identity:	98/390 - (25%)
Similarity:	174/390 - (44%)	Gaps:	69/390 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDK--IYHTKSDELFLIERLFESSLVAIVSQR 75
            |...::|||:.:....|...|..:|   :|:..::|  :.|.:...:.|:|.|..|:|:|:|...
Mouse     8 GVTSLHFNQDQSCFCCAMETGVRIY---NVEPLMEKGHLDHEQVGSVGLVEMLHRSNLLALVGGG 69

  Fly    76 APRKLKVCHF-----------KKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVV 129
            :..|......           .|...:..:::...:|||::..:::::.|...:|:::..|....
Mouse    70 SSPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPVLAVRMRHDKIVIVLRNRIYVYSFPDSPRK 134

  Fly   130 HTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKT-----MIPAHDTPLAAL 189
            ....||..||:|||.|..|.|...|.:||. ..|.:|:.|..:....|     .|.||.:.:|.:
Mouse   135 LFEFDTRDNPKGLCDLCPSLEKQLLVFPGH-KCGSLQLVDLASTKPGTSSAPFTINAHQSDVACV 198

  Fly   190 AFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVH 254
            :.:..||.:|:||::||:||:|.:|...:|.|||||... .::..::||..:.:|.:||:..|||
Mouse   199 SLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDP-ATLYCINFSHDSSFLCASSDKGTVH 262

  Fly   255 IF-----RLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTL 314
            ||     ||:|.:.....|.                 :...:..|:.:|        .:.||.|:
Mouse   263 IFALKDTRLNRRSALARVGK-----------------VGPMIGQYVDSQ--------WSLASFTV 302

  Fly   315 PEAGVRRMCAIA-TIQKQLRLLIA-SQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDIKVD 377
            | |....:||.. ...|.:..:|| ..||..:.| :.|.:| .|           :..|.|:.:|
Mouse   303 P-AESACICAFGRNTSKNVNSVIAICVDGTFHKY-VFTPDG-NC-----------NREAFDVYLD 353

Fly 378 377
Mouse 354 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	76/285 (27%)
		WD40	23..269	CDD:295369	72/268 (27%)
		WD40 repeat	143..180	CDD:293791	11/41 (27%)
		WD40 repeat	186..231	CDD:293791	18/44 (41%)
		WD40 repeat	232..258	CDD:293791	10/30 (33%)
Wdr45	NP_001277721.1	WD 1	4..42		9/36 (25%)
		WD40	<187..>274	CDD:392136	33/87 (38%)
		WD 2	190..230		15/39 (38%)
		WD40 repeat	196..232	CDD:293791	14/35 (40%)
		WD 3	235..274		12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950